Effect of 1-adamantyl radicals on curare-like activity

doi:10.1007/BF00800498

Paper

Effect of 1-adamantyl radicals on curare-like activity

Published May 1, 1975 · D. A. Kharkovich, A. P. Skoldinov

Bulletin of Experimental Biology and Medicine

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Abstract

The importance of hydrophobic 1-adamantyl radicals (Ad) for curare-like activity was investigated in a series of polymethylene bis-ammonium salts R(CH3)2N+(CH2)nN+(CH3)2R·21− (R=CH3 or Ad). Introduction of Ad radicals into the cationic groups of depolarizing agents (n=9–11) changed the mechanism of their action and lowered their activity. Addition of Ad radicals to the quaternary nitrogen atoms of antidepolarizing agents (n=5 and 6) sharply increased their curare-like activity. The results are evidence of the existence of hydrophobic zones in nicotinic cholinergic receptors of skeletal muscles.

In Vitro Study

Study Snapshot

Hydrophobic 1-adamantyl radicals significantly influence curare-like activity in skeletal muscles, with their introduction altering depolarizing agents' mechanisms and increasing antidepolarizing agents' activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effect of 1-adamantyl radicals on curare-like activity

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References

Differences in mode of neuromuscular blockade in a series of symmetric bis-quaternary ammonium salts.

The mode of neuromuscular blockade in symmetric bis-quaternary ammonium salts is influenced by distance between nitrogen atoms, chain structure, and chemical groups attached to the nitrogen atoms.

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