1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)-quinoline-3-carb oxylic acid, a new fluorinated compounds of oxacin family with high broad-spectrum antibacterial activities.

doi:10.1002/chin.198538228

Paper

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)-quinoline-3-carb oxylic acid, a new fluorinated compounds of oxacin family with high broad-spectrum antibacterial activities.

Published Apr 1, 1985 · G. Stefancich, M. Artico, F. Corelli

Il Farmaco; edizione scientifica

UNKNOWN SJR score

4

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

The synthesis of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)quinoline-3-carboxy lic acid, a new fluorinated high broad-spectrum antibacterial agent related to nalidixic acid is described. The title compound has been prepared by the reaction of 4-fluoro-3-(1H-pyrrol-1-yl)aniline with diethyl ethoxymethylenemalonate, cyclization of the malonate obtained to the quinolinecarboxylate ester, ethylation of the ester, followed by hydrolysis with aqueous sodium hydroxide. The new derivative proved very active against both gram-positive and gram-negative bacteria. Its activities in comparison with those of nalidixic acid, pipemidic acid, piromidic acid and enoxacin were found to be greatly superior with regard to the unfluorinated compounds and somewhat superior also to enoxacin. The known 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(pyrrolidin-1-yl)quinoline-3- carboxylic acid, here prepared by catalytic hydrogenation of the pyrrole moiety of the title compound, has been found to be less active as an antibacterial agent.

Study Snapshot

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)quinoline-3-carboxylic acid is a new fluorinated antibacterial agent with high broad-spectrum activity against both gram-positive and

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)-quinoline-3-carb oxylic acid, a new fluorinated compounds of oxacin family with high broad-spectrum antibacterial activities.

Sign up to use Study Snapshot

References

Citations

The war against bacteria, from the past to present and beyond

Novel antibiotics are needed to combat multidrug-resistant bacteria, as current treatments are insufficient to combat emerging infections.

New fluoroquinolones active against fluoroquinolones-resistant Mycobacterium tuberculosis strains.

New fluoroquinolones, particularly 2o and 2n, show promising activity against fluoroquinolone-resistant Mycobacterium tuberculosis, with potential for clinical use.

Effect of disintegrants with different hygroscopicity on dissolution of Norfloxacin/Pharmatose DCL 11 tablets.

Disintegrants with different hygroscopicity affect the dissolution of Norfloxacin/Pharmatose DCL 11 tablets, with higher hygroscopicity reducing the dissolution improvement effect of Pharmatose DCL 11.