2-(4-Fluorophenyl)-quinazolin-4(3H)-one as a novel tyrosinase inhibitor: Synthesis, inhibitory activity, and mechanism.

doi:10.1016/j.bmc.2016.07.068

Paper

DOI: 10.1016/j.bmc.2016.07.068

2-(4-Fluorophenyl)-quinazolin-4(3H)-one as a novel tyrosinase inhibitor: Synthesis, inhibitory activity, and mechanism.

Published Oct 1, 2016 · Rui Wang, Wei-Ming Chai, Qin Yang

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

The novel tyrosinase inhibitor 2-(4-Fluorophenyl)-quinazolin-4(3H)-one shows potential as a promising hyperpigmentation drug due to its reversible mixed-type inhibitory mechanism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Anti-Browning Effect of 2-Mercaptobenzo[d]imidazole Analogs with Antioxidant Activity on Freshly-Cut Apple Slices and Their Highly Potent Tyrosinase Inhibitory Activity

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Newly Designed Quinazolinone Derivatives as Novel Tyrosinase Inhibitor: Synthesis, Inhibitory Activity, and Mechanism

Q1 is a novel tyrosinase inhibitor with potential as a novel pigmentation drug due to its mixed-type and reversible nature.

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