2,5-Dimethylphenacyl as a new photoreleasable protecting group for carboxylic acids

doi:10.1021/OL005789X

Paper

2,5-Dimethylphenacyl as a new photoreleasable protecting group for carboxylic acids

Published May 5, 2000 · Klan, Zabadal, Heger

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46

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Abstract

The 2,5-dimethylphenacyl chromophore, a new photoremovable protecting group for carboxylic acids, is proposed. Direct photolysis of various 2,5-dimethylphenacyl esters in benzene or methanol at 254-366 nm leads to the formation of the corresponding carboxylic acids in almost quantitative isolated yields. The photodeprotection is based on efficient intramolecular hydrogen abstraction without the necessity of introducing a photosensitizer.

Study Snapshot

The 2,5-dimethylphenacyl chromophore effectively removes protecting groups from carboxylic acids, enabling their direct photolysis in benzene or methanol without the need for a photosensitizer.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

2,5-Dimethylphenacyl as a new photoreleasable protecting group for carboxylic acids

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References

Citations

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Searching for Improved Photoreleasing Abilities of Organic Molecules.

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The "supersilyl" group offers exceptional protection for carboxylic acid functionality and is a valuable tool in highly stereoselective aldol and Mannich reactions, with potential applications in rapid synthesis of polyketide subunits.