Effect of 2,6-diaminopurine on the Course of Russian Spring-Summer Encephalitis Infection in the Mouse.∗

doi:10.3181/00379727-78-19005

Paper

Effect of 2,6-diaminopurine on the Course of Russian Spring-Summer Encephalitis Infection in the Mouse.∗

Published Oct 1, 1951 · Alice E. Moore, Charlotte Friend

Proceedings of the Society for Experimental Biology and Medicine

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Abstract

Summary The compound 2,6-diamino-purine when administered in doses of 70 mg/kg caused an increase in the survival rates of mice infected with Russian Spring-Summer Encephalitis by the intraperitoneal route. It was effective when treatment was started 24 hours after the inoculation of the virus.

Non-RCT

Animal Study

Study Snapshot

2,6-diamino-purine, administered at 70 mg/kg, significantly increases survival rates in mice infected with Russian Spring-Summer Encephalitis when administered intraperitoneally 24 hours after virus inoculation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effect of 2,6-diaminopurine on the Course of Russian Spring-Summer Encephalitis Infection in the Mouse.∗

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References

Citations

Charlotte Friend, Ph.D. 1921‐1987 A Scientist's Life

During World War II, Charlotte Friend worked as a microbiology researcher in the U.S. Navy, where her work contributed to the development of antibiotics and the understanding of bacterial pathogenesis.

BIOLOGICAL ACTIVITIES OF SOME PURINE ARABINOSIDES

Ara-DAP shows potential as an effective antiviral agent against DNA viruses, with potential for improved therapeutic efficacy and longer half-life in vivo.

Antiviral Chemotherapy †

Antiviral chemotherapy effectively treats various infectious diseases caused by intracellular agents, potentially reducing the number of infecting particles and potentially killing the infecting agent.

STUDIES OF THE INFLUENCE OF 2,6‐DIAMINOPURINE UPON THE CONTENT OF KAPPA IN PARAMECIUM AURELIA, VARIETY 4

2,6-diaminopurine shows potential as a selective antimetabolite for neoplastic growth, potentially offering a new approach to cancer chemotherapy.

FACTORS CONCERNED WITH VIRAL PROLIFERATION IN VIVO

Viral multiplication in vivo is influenced by host cell genetics, metabolic state, presence of another virus, and extracellular environment, with antibodies effectively preventing infection but having minimal effect on viral proliferation.

Looking back in 2009 at the dawning of antiviral therapy now 50 years ago an historical perspective.

Antiviral therapy has evolved significantly since 1959, with 50 licensed compounds on the market for treating various viral infections, including 25 for HIV treatment.

The biochemical basis for the drug actions of purines.

The biological activity of purines is complex, with enzyme specificity and structural features determining their deactivation or destruction by catabolic enzymes, and resistance is a significant issue.