2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents

doi:10.2147/DDDT.S155958

Paper

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents

Published May 31, 2018 · G. Serban, O. Stănășel, E. Șerban

Drug Design, Development and Therapy

Q1 SJR score

106

Citations

1

Influential Citations

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Abstract

Pathogenic microorganisms are causative agents for different types of serious and even lethal infectious diseases. Despite advancements in medication, bacterial and fungal infections continue to be a growing problem in health care. As more and more bacteria become resistant to antibiotics used in therapy and an increasing number of invasive fungal species become resistant to current antifungal medications, there is considerable interest in the development of new compounds with antimicrobial activity. The compounds containing a heterocyclic ring play an important role among organic compounds with biological activity used as drugs in human and veterinary medicine or as insecticides and pesticides in agriculture. Thiadiazoles belong to the classes of nitrogen–sulfur heterocycles with extensive application as structural units of biologically active molecules and as useful intermediates in medicinal chemistry. The potency of the thiadiazole nucleus is demonstrated by the drugs currently used. 1,3,4-Thiadiazoles and some of their derivatives are extensively studied because of their broad spectrum of pharmacological activities. The aim of this review was to highlight the main antimicrobial properties exhibited by derivatives possessing 2-amino-1,3,4-thiadiazole moiety. Many of the reported 2-amino-1,3,4-thiadiazole derivatives can be considered as lead compounds for drug synthesis, and several of them have demonstrated higher antimicrobial activity in comparison to standard drugs. Furthermore, taking into account the reactivity of the amine group in the derivatization process, 2-amino-1,3,4-thiadiazole moiety may be a good scaffold for future pharmacologically active 1,3,4-thiadiazole derivatives.

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Study Snapshot

2-amino-1,3,4-thiadiazole derivatives show promising antimicrobial properties, offering a promising scaffold for future pharmacologically active 1,3,4-thiadiazole derivatives.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents

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References

Citations

Multitarget Pharmacology of Sulfur–Nitrogen Heterocycles: Anticancer and Antioxidant Perspectives

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The study optimized functionalization of 2-mercapto-5-methyl-1,3,4-thiadiazole to produce 2-(-haloalkylthio)thiadiazoles and symmetrical bis-thiadiazoles, yielding two series of products with variable chain lengths.

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