A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.

doi:10.1021/ja9024676

Paper

A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.

Published Jul 2, 2009 · S. Rogers, R. W. Huigens, C. Melander

Journal of the American Chemical Society

Q1 SJR score

76

Citations

3

Influential Citations

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Abstract

A number of 2-aminobenzimidazole derivatives were synthesized and screened for their ability to inhibit and disperse bacterial biofilms. From these compounds, a lead 2-aminobenzimidazole was identified that both inhibited and dispersed MRSA, vancomycin-resistant Enterococcus faecium, and Staphylococcus epidermidis biofilms. Mechanistic studies showed that the activity is Zn(II)-dependent, potentially via a direct zinc-chelating mechanism.

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Study Snapshot

The 2-aminobenzimidazole effectively inhibits and disperses gram-positive biofilms, potentially through a zinc-chelating mechanism, making it a potential antimicrobial agent.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.

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References

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Citations

Characterization of Salmonella enterica Biofilms and Antibiofilm Effect of Carvacrol and 2-Aminobenzimidazole.

Carvacrol and 2-aminobenzimidazole effectively inhibit Salmonella biofilm formation in poultry, suggesting their potential as supportive or alternative antimicrobials.

Synthetic non-toxic anti-biofilm agents as a strategy in combating bacterial resistance.

Anti-biofilm agents, which inhibit biofilm production without affecting bacterial growth, can potentially combat bacterial resistance by applying less selective pressure than traditional antibiotics.

Evaluation of the Antibacterial and Antibiofilm Effects of Ethyl Acetate Root Extracts from Vernonia adoensis (Asteraceae) against Pseudomonas aeruginosa

Ethyl acetate root extracts from Vernonia adoensis effectively inhibit Pseudomonas aeruginosa growth and inhibit biofilm formation, potentially offering a new antibacterial agent against resistant pathogens.

2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner

AB-2-29, a 2-aminoimidazole compound, effectively inhibits Mycobacterium abscessus biofilm formation and is potentiated by zinc addition, offering potential for effective treatment of Mycobacterium abscessus infections.

Zinc Deprivation as a Promising Approach for Combating Methicillin-Resistant Staphylococcus aureus: A Pilot Study

Zinc deprivation can potentially reduce MRSA growth, biofilm formation, and hemolytic activity, potentially aiding in the treatment of topical infections.