2-(Aminomethyl)phenols, a new class of saluretic agents. 1. Effects of nuclear substitution.

doi:10.1021/JM00186A024

Paper

2-(Aminomethyl)phenols, a new class of saluretic agents. 1. Effects of nuclear substitution.

Published Dec 1, 1980 · G. Stokker, A. Deana, S. Desolms

Journal of medicinal chemistry

Q1 SJR score

26

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1

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Abstract

A series of 2-(aminomethyl)phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration. The most active compounds belong to a subseries of 4-alkyl-6-halo derivatives of which 2, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol, is the most active. Compound 2 also possesses significant antihypertensive activity, an adjunctive pharmacological parameter which distinguishes 2 from the other compounds prepared in this series. In addition, 2 displays both topical saluretic and antiinflammatory activities.

Non-RCT

Animal Study

Study Snapshot

2-(aminomethyl)phenols show high saluretic and diuretic activity, with compound 2 showing significant antihypertensive activity and topical saluretic and antiinflammatory properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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2-(Aminomethyl)phenols, a new class of saluretic agents. 1. Effects of nuclear substitution.

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