B. Raju, Chengde Wu, R. Castillo
Aug 19, 1997
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Influential Citations
10
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Quality indicators
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract A series of 2-aryloxycarbonylthiophene-3-sulfonamides were synthesized and evaluated to determine their antagonistic activity at the endothelin receptors. N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(3,4-methylenedioxy)phenoxycarbonyl]thiophene-3-sulfonamide was identified as a highly selective, potent (IC 50 = 8.3 nM) and low molecular weight nonpeptide antagonist.