Geoffrey M. Mahanga, Teresa O. Akenga, W. Lwande
2005
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
Bulletin of The Chemical Society of Ethiopia
Abstract
2-Hydroxy-4-methoxybenzaldehyde (1) , a compound isolated from Mondia whytei (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD 50 22 mg/mL). A total of 18 other derivatives and closely related congeners revealed varying levels of larvicidal activity. Several closely related congeners, like 2-benzyloxy-4-methoxybenzaldehyde (2) , 2-hydroxybenzaldehyde (12) , 2-benzyloxybenzaldehyde (3) and benzylphenyl ether (4) , showed marked improvement in activity (LD 50 10, 9, 4.8, 1.2 mg/mL, respectively) against Anopheles gambiae larvae. 2-Benzoyloxy-4-methoxybenzaldehyde (5) exhibited similar activity level (LD 50 28 mg/mL) as 1 . KEY WORDS : 2-Hydroxy-4-methoxybenzaldehyde, Larvicides, Structure-activity relationships, 2-Hdroxybenzaldehyde, 2-Benzyloxybenzaldehyde, Benzylphenyl ether Anopheles gambiae , Bull. Chem. Soc. Ethiop. 2005, 19(1), 61-68.