Dagmar Scharnagel, Felix Prause, Johannes Kaldun
May 28, 2014
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0
Influential Citations
26
Citations
Journal
Chemical communications
Abstract
A cis-2-aminomethyl-5-phenylpyrrolidine, which is easily available from methyl Boc-L-pyroglutamate, was found to be a highly efficient chiral ligand for Cu(II)-catalysed Henry reactions. Excellent yields (>90%) and superb levels of enantiocontrol (98.5-99.6% ee) were reached with aromatic, heteroaromatic, vinylic, and aliphatic aldehydes (36 examples).