2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.

doi:10.1021/acs.jafc.1c01305

Paper

2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.

Published Apr 20, 2021 · Xueyan Wu, Jing Li, Shaopeng Wang

Journal of agricultural and food chemistry

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21

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3

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Abstract

Exposure to particulate matter has been associated with diseases of the respiratory and cardiovascular systems. Owing to the dense vasculature of the kidney, it has also been identified as a PM2.5 target organ. A potential contributor to PM2.5-mediated damage may be the promotion of inflammation. The essential oil 2-undecanone (2-methyl nonyl ketone) is an H. cordata isolate, and it has been shown to possess diverse pharmacologic effects, including anti-inflammatory properties. In this study we explored the ability of 2-undecanone to protect against PM2.5-induced kidney inflammation and the exact mechanisms in this process. We found that PM2.5 elevated the levels of certain inflammatory cytokines in BALB/c mice and in HEK 293 cells. Supplementation with 2-undecanone attenuated this PM2.5-induced inflammatory injury. Interestingly, in HEK 293 cells, the PM2.5-associated inflammation was aggravated by the mitophagy inhibitor Medivi-1, while it was attenuated by rapamycin, indicating that the mechanism of 2-undecanone-mediated inhibition of inflammation may relate to mitophagy. Meanwhile, 2-undecanone induces mitophagy in HEK 293 cells by suppressing Akt1-mTOR signaling. These results indicate that PM2.5 can induce kidney inflammation, and mitophagy induced by 2-undecanone may play a protective role against this renal inflammation.

In Vitro Study

Study Snapshot

2-undecanone protects against PM2.5-induced kidney inflammation by inducing mitophagy, suggesting its potential as a potential treatment for PM2.5-induced kidney inflammation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.

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Citations

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