3‐O‐Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress

doi:10.1111/exd.13820

Paper

3‐O‐Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress

Published Jan 30, 2019 · Y. Katsuyama, N. Taira, T. Tsuboi

Experimental Dermatology

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6

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Abstract

Skin sensitivity is a serious problem for many people, and it can be induced by various factors such as UV irradiation, physical and mental stresses, air pollution, dry air and so on. Skin dryness triggered by UV and dry air is one of the most important causes inducing the development of sensitive skin, and it has been reported that oxidative stress contributes to skin dryness. In this study, we investigated whether treatment with 3‐O‐laurylglyceryl ascorbate (VC‐3LG), which is an amphipathic ascorbic acid derivative, can suppress the development of sensitive skin. The results demonstrate that VC‐3LG restores the expression levels of interleukin‐1α, nerve growth factor and matrix metalloprotease‐9 in the dry skin models of reconstructed human epidermal equivalents (RHEEs) and in H2O2‐treated keratinocytes. In addition, VC‐3LG suppresses the dendrite elongation of nerve cells induced in RHEEs by dry skin conditions and by H2O2 treatment of keratinocytes. Therefore, we consider that treatment of the skin with VC‐3LG is an effective approach to improve the development of sensitive skin.

In Vitro Study

Study Snapshot

3O-laurylglyceryl ascorbate effectively improves sensitive skin development by reducing oxidative stress and restoring nerve cell function in dry skin models.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

3‐O‐Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress

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References

3-O-Laurylglyceryl ascorbate activates the intracellular antioxidant system through the contribution of PPAR-γ and Nrf2.

VC-3LG has an antioxidant effect by reducing intracellular reactive oxygen species levels and stimulating intracellular antioxidants like GSH through the PPAR- and Nrf2 signaling pathways.

The possible involvement of skin dryness on alterations of the dermal matrix

Skin dryness contributes to alterations in the dermal matrix through the elevation of MMP-1 secretion, potentially causing wrinkle formation.

Itch and nerve fibers with special reference to atopic dermatitis: Therapeutic implications

Anti-NGF treatments, Sema3A replacement, and ultraviolet-based therapies can effectively suppress itching in atopic dermatitis by normalizing nerve hyperinnervation.

Sensitive skin: an overview

Sensitive skin is characterized by hyper-reactivity to environmental factors, often caused by factors such as thinner stratum corneum, altered vanilloid receptors, and changes in neuronal transmission.

Decreased expression of semaphorin-3A, a neurite-collapsing factor, is associated with itch in psoriatic skin.

Decreased semaphorin-3A and increased nerve growth factor expression levels in psoriatic skin may trigger the outgrowth of sensory C-fibres, leading to pruritus.

Citations

Management of triggering factor effects in sensitive skin syndrome with a dermo‐cosmetic product

A specific dermo-cosmetic product can prevent unpleasant symptoms and improve the skin state in sensitive skin syndrome exposed to physical and chemical triggering factors.

Anti‐allergic effect of ascorbic acid derivative DDH‐1 in a mouse model of atopic dermatitis

DDH-1, an ascorbic acid derivative, effectively reduces allergic skin inflammation in atopic dermatitis mice by suppressing pro-inflammatory cytokine expression and Th2 chemokine expression.

Human skin responses to environmental pollutants: A review of current scientific models.

Pollutants alter human skin's elasticity, thickness, and barrier strength, leading to skin conditions like psoriasis, atopic dermatitis, and tumor development.

TLR4 knock out alleviate both lung and liver inflammation caused by short-time exposure to PM2.5

TLR4 knockout mice can reduce lung and liver inflammation caused by short-time exposure to PM2.5, suggesting its importance in regulating air pollution-induced inflammation.

Fostering a healthy culture: Biological relevance of in vitro and ex vivo skin models

3D organotypic cultures provide a more accurate model for studying complex human skin behaviors, bridging the gap between in vitro and ex vivo conditions.