M. El-hashash, S. Rizk, E. A. Ahmed
Feb 1, 2012
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0
Influential Citations
4
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Journal
Chemistry: A European Journal
Abstract
The present work deals with the generation and synthesis of different heterocycles such as 2-pyrimidine thione, pyrane, pyridine and phthalazinone derivative via the treatment of 3-(4-bromobenzoyl)prop-2-enoic acid with thiourea, ethylcyanoacetate malononitrile& acetylacetone in presence of amm.acetate and/or piperidine respectively.Additionally, utility of 2-amino-3-cyano-4-carboxy-6-(4-bromophenyl)3,4-dihydropyridine (4) as a key starting material to synthesize some important heterocycles include fused pyrido-pyrimidine,fused pyrido- pyridazinopyrimidine and interesting dihet- erocyclic amines.