3-(4-Thiocarbamoyl-1,2,3-triazol-1-yl)benzo-15-crown-5: synthesis and properties

doi:10.1007/S11172-010-0177-1

Paper

3-(4-Thiocarbamoyl-1,2,3-triazol-1-yl)benzo-15-crown-5: synthesis and properties

Published Oct 21, 2010 · P. Prokhorova, T. Glukhareva, L. V. Dyudya

Russian Chemical Bulletin

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5

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Abstract

A reaction of 1,2,3-thiadiazole-4-carbaldehyde with 3-aminobenzo-15-crown-5 involves the Cornforth rearrangement of the 1,2,3-thiadiazole ring, which leads to 1,2,3-triazole-4-carbothioamide containing the benzocrown ether substituent in position 1 of the triazole ring. Reversible formation of the isomeric thiadiazole occurs in aprotic nonpolar solvents such as deuterated chloroform. These compounds are suitable for extraction of α-amino acids from an aqueous phase.

Study Snapshot

This study presents a novel method for synthesizing 1,2,3-triazole-4-carbothioamide, a useful compound for extracting -amino acids from aqueous phases.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

3-(4-Thiocarbamoyl-1,2,3-triazol-1-yl)benzo-15-crown-5: synthesis and properties

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References

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Synthetic ditopic receptors can simultaneously bind both cationic and anionic guests, potentially enhancing ion-pair recognition and enhancing ion-pair complexation.

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Anion recognition chemistry has advanced to include diverse supramolecular host systems for selective complexation, detection, and separation of anionic guest species, with pH values playing crucial roles in the overall anion recognition process.

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Organic solvents impact chemical equilibrium positions, reaction rates, and absorbtion spectra, with various classification methods and green chemistry implications.

Citations

Progress in intermolecular and intramolecular reactions of thioamides with diazo compounds and azides

Recent advances in catalysts and sulfonyl azides have led to new methods for synthesizing heterocycles, enamines, and N-sulfonyl amidines in organic synthesis.

1,2,3-Thiadiazolyl Isocyanates in the Synthesis of Biologically Active Compounds. Study of the Cytotoxic Activity of N-(4-methyl-1,2,3-thiadi-azolyl-5-yl)-N'-(4-methylphenyl)Urea*

This study presents a simple method for synthesizing 1,2,3-thiadiazolylureas, which shows potential as biologically active compounds, and demonstrates the cytotoxic activity of N-(4-methyl-1,2,3-thiadi-azolyl-5-yl)-N'

Recent Developments in the Chemistry of 1,2,3-Thiadiazoles

1,2,3-thiadiazole synthesis and biological properties have advanced significantly since 2003-17, with new methods and insights into their chemical properties.