A. Becker
1984
Citations
0
Influential Citations
3
Citations
Journal
Australian Journal of Chemistry
Abstract
The three isomeric ring monochlorinated derivatives of 3-amino-5-hydroxybenzoic acid (1), required for studies of the biosynthesis and synthesis of several important classes of antibiotics, are prepared from methyl 3-amino-5-hydroxybenzoate (5). N-Chlorosuccinimide selectively monochlorinates the 2- and 6-positions of this substrate, whilst perchlorination followed by hydrolysis and regiospecific protodechlorination at the 2- and 6-positions affords the 4-chloro acid.