Younho Lee, Y. Shin, S. Ahn
Mar 1, 2014
Citations
0
Influential Citations
6
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Many adamantane derivatives have been demonstrated to function as 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. 3-Amino-N-adamantyl-3-methylbutanamide derivatives were optimized by structure-based drug design. Compound 8j exhibited a good in vitro and ex vivo inhibitory activity against both human and mouse 11β-HSD1.