C. T. Hoang, V. Nguyen, V. Alezra
Jan 5, 2008
Citations
0
Influential Citations
14
Citations
Journal
The Journal of organic chemistry
Abstract
The antipsychotic compound nemonapride 1 was synthesized in nine steps from d-alanine 2. The key steps for the synthesis of the 3-aminopyrrolidine moiety include a Birch reduction of a cyclic enaminoester and the reduction of a pyrrolidinone to the pyrrolidine 7. Final coupling with the benzoic acid derivative 9 gave 1 as a single enantio- and diastereomer.