3-(IMIDAZOL-1-YL)PROPANE-1,2-DIOL AND 3-(1,2,4- TRIAZOL-1-YL)PROPANE-1,2-DIOL: SYNTHESIS AND THEIR TRANSFORMATION TO BIOACTIVE CYCLIC KETALS

doi:10.31788/rjc.2021.1436537

Paper

3-(IMIDAZOL-1-YL)PROPANE-1,2-DIOL AND 3-(1,2,4- TRIAZOL-1-YL)PROPANE-1,2-DIOL: SYNTHESIS AND THEIR TRANSFORMATION TO BIOACTIVE CYCLIC KETALS

Published 2021 · V. Talismanov, S. V. Popkov, O. G. Karmanova

Rasayan Journal of chemistry

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1

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Abstract

3-(Imidazol-1-yl)propane-1,2-diol and 3-(1,2,4-triazol-1-yl)propane-1,2-diol were obtained by three alternative synthetic pathways such as hydrolysis of 1-[(1,3-dioxolan-4-yl)methyl]-azoles, Wagner reaction of N-allylazoles and reaction of glycidol with imidazole or 1,2,4-triazole. The 4-(azol-1-ylmethyl)-1,3-dioxolanes can be synthesized by reaction of 3-(imidazol-1-yl)propane-1,2-diol or 3-(1,2,4-triazol-1-yl)propane-1,2-diol with ketones to substituted 4azolylmethyl-1,3-dioxolanes

Study Snapshot

This study demonstrates that 3-(Imidazol-1-yl)propane-1,2-diol and 3-(1,2,4-triazol-1-yl)propane-1,2-diol can be synthesized and converted to bioactive cyclic ketoals through various synthetic pathways

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

3-(IMIDAZOL-1-YL)PROPANE-1,2-DIOL AND 3-(1,2,4- TRIAZOL-1-YL)PROPANE-1,2-DIOL: SYNTHESIS AND THEIR TRANSFORMATION TO BIOACTIVE CYCLIC KETALS

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References

Citations

Synthesis and pesticidal activity of some 4-Azolylmethyl-1,3-dioxolanes, based on cyclic ketones

Substituted 1,3-dioxolanes based on cyclic ketones show lower fungicidal activity than triadimefon and spiroxamine, but show noticeable retardant properties.