R. Srivastava, Robert R. Singhaus, G. Kabalka
Oct 27, 1999
Citations
0
Influential Citations
33
Citations
Journal
Journal of Organic Chemistry
Abstract
A series of 4-dihydroxyborylphenyl analogues of an unnatural α-amino acid, 1-aminocyclobutanecarboxylic acid (ACBC), was synthesized. Varying numbers of methylene units were introduced between the 4-boronophenyl and ACBC moieties in order to introduce different degrees of lipophilicity into the molecules. The key step in the syntheses was the preparation of the precursor p-boronophenyl-substituted cyclobutanones which were subsequently converted to the desired amino acids via the Bucherer−Strecker reaction.