T. Fukuyama, Chung-Kuang Jow, Mui Cheung
Sep 4, 1995
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0
Influential Citations
620
Citations
Quality indicators
Journal
Tetrahedron Letters
Abstract
Abstract 2- and 4-Nitrobenzenesulfonamides, readily prepared from primary amines, undergo smooth alkylation by Mitsunobu reaction or by conventional methods to give N-alkylated sulfonamides in near quantitative yields. These sulfonamides could be deprotected readily via Meisenheimer complexes upon treatment with thiolates in DMF at room temperature, giving secondary amines in high yields.