L. Hu, B. Liu, D. Hacking
Apr 1, 2000
Citations
0
Influential Citations
18
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine was synthesized as a potential bioreductively activated prodrug of 5-fluoro-2'-deoxyuridine (FUDR). The target compound was stable in both phosphate buffer and human serum and was found to release quickly the parent drug FUDR in quantitative yield upon mild chemical reduction.