5-benzyloxy-2-thiocyanatomethyl-4-pyranone, a novel heterocyclic compound: synthesis, structure determination and effects on neoplastic cell growth.

Paper

5-benzyloxy-2-thiocyanatomethyl-4-pyranone, a novel heterocyclic compound: synthesis, structure determination and effects on neoplastic cell growth.

Published Mar 1, 1997 · J. Bransová, M. Uher, L. Novotný

Anticancer research

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12

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0

Influential Citations

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Abstract

The present study was undertaken to prepare a novel 4-pyranone compound 5-benzylaxy-2-thiocyanatomethyl-4-pyranone as well as to investigate its effects on neoplastic cell growth. Three cell lines (murine leukemia L1210, human leukemia K562 and rat pituitary GH4C1 cells) were used in our experiments. The cell growth, DNA, RNA, protein synthesis, and cytoplasmatic protein phosphorylation after the treatment of GH4C1 cells with 5-benzyloxy-2-thiocyanatomethyl-4-pyranone were investigated. We found that the above new 4-pyranone derivative at 2.6 microM significantly (p < 0.05) inhibits neoplastic cell growth, and inhibits (p < 0.05) DNA synthesis.

In Vitro Study

Study Snapshot

The novel 4-pyranone compound 5-benzyloxy-2-thiocyanatomethyl-4-pyranone significantly inhibits neoplastic cell growth and DNA synthesis in rat pituitary GH4C1 cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

5-benzyloxy-2-thiocyanatomethyl-4-pyranone, a novel heterocyclic compound: synthesis, structure determination and effects on neoplastic cell growth.

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References

Citations

Kojic Acid: A Comprehensive Review

Kojic acid has diverse applications in various industries, including cosmetics, medicine, food, agriculture, and chemical, but its instability and cytotoxicity may limit its widespread use.

Evaluate the Cytotoxicity of Kojic Acid Nanocomposites on Melanoma Cells and Normal Cells of the Skin

Kojic acid nanocomposites show significant cytotoxicity in skin cancer cells, with an IC50 value of 47.1 and 8.4 g/mL, respectively, compared to normal skin cells.

Cytotoxic activity assessment, QSAR and docking study of novel bis-carboxamide derivatives of 4-pyrones synthesized by Ugi four-component reaction.

Novel bis-carboxamide derivatives of 4-pyrones show strong cytotoxic potential in HL-60 cells, with compound 12n being the most potent, and their topological properties directly influence their cytotoxic potential.

Fragmentation of some 4H-pyran-4-one and pyridin-4-one derivatives under electron impact

Electron impact on 13 compounds of the 4H-pyran-4-one and pyridin-4-one series leads to formation of rearrangement ions and neutral molecules with low enthalpies of formation.

In vitro antiproliferative and cytotoxic activities of novel kojic acid derivatives: 5‐benzyloxy‐2‐selenocyanatomethyl‐ and 5‐methoxy‐2‐selenocyanatomethyl‐4‐pyranone

Novel selenium-containing kojic acid derivatives show antiproliferative properties, targeting intracellular compartments rather than the plasma membrane, expanding the group of antiproliferative active compounds.

Kojic acid and its derivatives: history and present state of art.

Kojic acid derivatives show promising potential for use in human and veterinary medicine and for the development of new, more biologically active preparations.

Protection of newborn organism against effect of oxidative stress.

Asphyxial newborns show increased oxidative stress and decreased antioxidant capacity compared to adult patients, indicating a need for early intervention in newborn protection.