Paper
Effect of 5-iodo-2'-deoxyuridine on the biosynthesis of phosphorylated derivatives of thymidine.
Published Feb 1, 1962 · I. Delamore, W. Prusoff
Biochemical pharmacology
Q1 SJR score
62
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
5-iodo-2'-deoxyuridine (IUDR) inhibits DNA-thymidine biosynthesis in various neoplastic tissues, with specific metabolic sites affected in individual tissues.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
The effect of 5-iododeoxyuridine upon the growth of some transplantable rodent tumors.
5-iododeoxyuridine effectively inhibits the growth of Sarcoma 180 and lymphomas L1210 and L5178-Y in mice without significant host toxicity, but is ineffective in rats with Walker carcinosarcoma 256.
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Iododeoxyuridine can be incorporated into the DNA of mouse Ehrlich ascites tumor cells in vivo, with similar results when the amount injected is increased and the frequency of administration doubled.
1960·55citations·W. Prusoff·Biochimica et biophysica acta
Biochimica et biophysica acta
Incorporation of 5-Iodouracil labelled with Iodine-131 into the Deoxyribonucleic Acid of Human Leukæmic Leucocytes following in vivo Administration of 5-Iododeoxyuridine labelled with Iodine-131
Incorporation of 5-iodouracil labelled with Iodine-131 into human leukemia leucocytes' deoxyribonucleic acid can be used to study nucleic acid metabolism in various tissues with extensive cell proliferation.
1959·45citations·M. L. Eidinoff et al.·Nature
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Incorporation of thymidine into deoxyribonucleic acid by enzymes from rat tissues.
Rat tissue enzymes can incorporate radioactive thymidine into deoxyribonucleic acid, demonstrating their potential as a tool for studying cellular processes in regenerating rat liver and other tissues.
1958·195citations·F. Bollum et al.·The Journal of biological chemistry
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Citations
Biochemical modulation in the treatment of advanced cancer: a study of combined leucovorin, fluorouracil, and iododeoxyuridine.
A leucovorin-fluorouracil-iododeoxyuridine chemotherapy regimen shows potential in treating advanced colorectal cancer, with potential for higher response rates and reduced toxicity.
1996·0citations·J. Marshall et al.·Clinical cancer research : an official journal of the American Association for Cancer Research
Clinical cancer research : an official journal of the American Association for Cancer Research
AN EVALUATION OF RADIOIODINE‐LABELED 5‐IODO‐2′‐DEOXYURIDINE AS A TRACER FOR MEASURING CELL LOSS FROM SOLID TUMORS *
Radioiodine-labeled 5'-deoxyuridine (IUdR) is a reliable and sensitive tracer for measuring cell loss in solid tumors, with potential applications in clinical trials.
1971·46citations·L. Dethlefsen·Cell Proliferation
Cell Proliferation
Regulation of thymidine kinase activity by 5-iodo-2'-deoxyuridine 5'-triphosphate and deoxythymidine 5'-triphosphate.
The halogenated triphosphate derivative, 5-iodo-2'-deoxyuridine 5'-triphosphate, has a greater inhibitory effect and protects thymidine kinase from thermal inactivation than deoxythymidine 5'-triphosphate.
1970·19citations·W. Prusoff et al.·Chemico-biological interactions
Chemico-biological interactions
A clonal study of the reversible inhibition of muscle differentiation by the halogenated thymidine analog 5-bromodeoxyuridine.
The thymidine analog 5-bromodeoxyuridine (BUdR) can reversibly inhibit muscle differentiation, with no detectable effect on postmitotic cells or muscle fibers.
1969·101citations·J. R. Coleman et al.·Developmental biology
Developmental biology
The effect of 5-iodo-2'-deoxyuridine and its mono- and triphosphates on some enzymes concerned with the biosynthesis of DNA in cell-free extracts of murine neoplastic cells.
Cell-free extracts of Ehrlich ascites carcinoma and L5178Y lymphoma cells show no primary inhibition of DNA polymerase or thymidylate kinase, suggesting a possible explanation for the divergence in results between whole cell and cell-free experiments.
1969·5citations·Y. S. Bakhle et al.·Biochimica et biophysica acta
Biochimica et biophysica acta
Mechanisms responsible for the low incorporation into DNA of the thymidine analogue, 5-iodo-2'-deoxyuridine.
IdU is less readily incorporated into DNA than dT, with a low level of IdUTP formation potentially accounting for this poor incorporation.
1968·30citations·L. Baugnet-Mahieu et al.·Biochemical pharmacology
Biochemical pharmacology
Untersuchungen über die Vermehrung eines adeno-ähnlichen Hühnervirus (CELO)
Increased incubation temperatures of 40°C significantly accelerate the growth cycle of CELO in chicken-kidney-tissue cultures, but the ratio of cell-associated to free virus remains constant.
1967·1citation·G. Monreal·Archiv für die gesamte Virusforschung
Archiv für die gesamte Virusforschung