Michael B. Smith, B. Dembofsky, Y. Son
Apr 1, 1994
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0
Influential Citations
28
Citations
Journal
Journal of Organic Chemistry
Abstract
We have prepared a new chiral nonracemic reagent (5(R)-methyl-1-(chloromethyl)-2-pyrrolidinone) in enantiopure form that reacts with alcohols containing a stereogenic center to produce diastereomeric N-(alkoxymethyl)-2-pyrrolidinone derivatives. These derivatives exhibit large and easily observed diastereotopic signals in the proton NMR that allow direct determination of diastereomeric ratio (% dr) for the product