Effect of 6-dehydro-DOCA and 6-dehydro-9 alpha-fluorocortisol acetate on the excretion of sodium and potassium in the rat.

doi:10.1016/0022-4731(85)90021-4

Paper

Effect of 6-dehydro-DOCA and 6-dehydro-9 alpha-fluorocortisol acetate on the excretion of sodium and potassium in the rat.

Published Nov 1, 1985 · P. Genard, M. Palem-Vliers

Journal of steroid biochemistry

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Abstract

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Study Snapshot

6-dehydro-derivatives of deoxycorticosterone acetate and 9-fluorocortisol acetate significantly alter sodium and potassium excretion in rats, suggesting a Type II receptor mediation of these ion fluxes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effect of 6-dehydro-DOCA and 6-dehydro-9 alpha-fluorocortisol acetate on the excretion of sodium and potassium in the rat.

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References

Structural, functional and hypertensive effects of 19-oxo-11-deoxycorticosterone acetate (19-oxo-DOCA) in the rat

19-oxo-11-deoxycorticosterone acetate (19-oxo-DOCA) in sesame oil does not affect blood pressure, growth, or kidney size, but causes hypernatremia and hypokalemia in rats.

Physico-chemical characterization of cytosol and nuclear mineralocorticoid receptors in rat kidney.

Two forms of mineralocorticoid receptors exist in rat kidney, with one cytosolic form being electrophoretically identical to the aldosterone-protein complex in the nuclear fraction.

Structure-activity relationships for agonistic and antagonistic mineralocorticoids.

The molecular structure of mineralocorticoids reveals that a slight conformational change in the hydrophobic site can decrease their activity and cause antagonistic effects against DOCA, 9-fluorocortisol, and aldosterone.

Aldosterone: current concepts.

Aldosterone's antinatriuretic and kaliuretic effects are separable, with distinct biochemical events occurring before and during their physiologic effects.

Protein measurement with the Folin phenol reagent.

The Folin phenol reagent is a sensitive and simple method for measuring proteins in serum, antigen-antibody precipitates, and insulin, but its limitations require further study for full exploitation.

Dihydrocortisol: a potential mineralocorticoid.

Dihydrocortisol (5-DHF) is a potential mineralocorticoid with weak glucocorticoid properties, suggesting it may play a role in hypertension.

Citations

The selective mineralocorticoid receptor modulator AZD9977 reveals differences in mineralocorticoid effects of aldosterone and fludrocortisone

AZD9977's contradictory effects on urinary electrolyte excretion in rats and humans are due to the synthetic mineralocorticoid fludrocortisone, not aldosterone.

Experimental Cardiac Hypertrophy Induced by Oral Administration of Mineralocorticoid and Saline in Rats

Orally administered fludrocortisone/salt effectively induces moderate myocardial hypertrophy in rats without heart failure in 4 weeks, providing a low-cost model for hypertrophic heart disease.

Effect of various 6-dehydro-corticosteroids, 9, 11-dehydro-DOCA and 9 alpha-fluoro-DOCA on the fluxes of sodium and potassium.

6-dehydro-corticosteroids, which reduce affinity for Type II receptors, increase sodium retention and compete with mineralocorticoids for Type I receptors, affecting urinary sodium and potassium excretion.