Paper
A complex between 6-iodolactone and the peroxisome proliferator-activated receptor type gamma may mediate the antineoplastic effect of iodine in mammary cancer.
Published Jun 1, 2009 · R. Nuñez-Anita, Omar Arroyo-Helguera, Marcos Cajero-Juárez
Prostaglandins & other lipid mediators
Q2 SJR score
36
Citations
4
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Iodine treatment in breast cancer cells inhibits growth by forming 6-iodolactone complexes with PPARs, which may play a molecular role in the antiproliferative effect of iodine.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory is a world-renowned research institute focused on cancer, quantitative biology, neurobiology, and plant genetics, offering professional education and the PhD degree.
2014·1075citations·Jan A. Witkowski·Current Biology
Current Biology
Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects.
Molecular iodine and 6-iodolactone both cause cell cycle arrest and apoptosis in breast cells, with 6-IL potentially playing a role in mammary cancer by forming 6-IL in tumor cells.
2008·44citations·Omar Arroyo-Helguera et al.·Endocrine-related cancer
Endocrine-related cancer
Uptake and gene expression with antitumoral doses of iodine in thyroid and mammary gland: evidence that chronic administration has no harmful effects.
High doses of iodine (0.05%) can effectively treat mammary tumors without harming thyroid or general physiology, suggesting its potential use in breast cancer therapies.
2007·30citations·B. Anguiano et al.·Thyroid : official journal of the American Thyroid Association
Thyroid : official journal of the American Thyroid Association
Uptake and antiproliferative effect of molecular iodine in the MCF-7 breast cancer cell line.
Molecular iodine (I2), not dependent on NIS or PDS, is taken up by a facilitated diffusion system and bound to lipids or proteins, inhibiting proliferation in MCF-7 breast cancer cells.
2006·69citations·O. Arroyo-Helguera et al.·Endocrine-related cancer
Endocrine-related cancer
Molecular Iodine Induces Caspase-independent Apoptosis in Human Breast Carcinoma Cells Involving the Mitochondria-mediated Pathway*
Molecular iodine activates a caspase-independent and mitochondria-mediated apoptotic pathway in human breast cancer cells, potentially offering a potential treatment for breast cancer.
2006·135citations·Ashutosh Shrivastava et al.·Journal of Biological Chemistry
Journal of Biological Chemistry
Citations
The correlation between iodine and metabolism: a review
Iodine intake may be linked to metabolic disorders, but the mechanisms and results of these associations remain inconclusive.
2024·4citations·Le Zhang et al.·Frontiers in Nutrition
Frontiers in Nutrition
Iodine Promotes Glucose Uptake through Akt Phosphorylation and Glut-4 in Adipocytes, but Higher Doses Induce Cytotoxic Effects in Pancreatic Beta Cells
Iodine influences glucose metabolism in mature adipocytes and insulin secretion in pancreatic beta cells, but excessive levels may cause cytotoxic damage to pancreatic beta cells.
2024·3citations·Reséndiz-Jiménez Arely et al.·Biology
Biology
Iodine-Biofortified Lettuce Can Promote Mitochondrial Dependent Pathway of Apoptosis in Human Gastrointestinal Cancer Cells
Iodine-biofortified lettuce can induce apoptosis in gastric and colon cancer cells through various signaling pathways, potentially offering a potential treatment for these diseases.
2023·4citations·Olga Sularz et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences
Protective effects of iodine on rat prostate inflammation induced by sex hormones and on the DU145 prostate cancer cell line treated with TNF
Iodine and testosterone together effectively reduce prostate inflammation and anti-proliferative effects in prostate cancer cells, with no involvement of PPARG in this process.
2023·0citations·B. Anguiano et al.·Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology
6 Iodo-delta lactone inhibits angiogenesis in human HT29 colon adenocarcinoma xenograft.
IL- inhibits tumor growth and angiogenesis in human HT29 colorectal cancer xenografts by inducing apoptosis and decreasing VEGF and VEGF-R2 expression, while increasing VEGF-R1 and Ang-1 mRNA levels.
2022·2citations·Oglio Romina et al.·Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids