6-Methoxy-1, 2, 3, 4-tetrahydro-β-carboline effects on retinal serotonin

doi:10.1016/0024-3205(79)90421-1

Paper

6-Methoxy-1, 2, 3, 4-tetrahydro-β-carboline effects on retinal serotonin

Published Oct 15, 1979 · T. N. Thomas, N. Buckholtz, J. W. Zemp

Life Sciences

Q1 SJR score

24

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0

Influential Citations

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

6-MeO-THC inhibits serotonin uptake in the retina and increases serotonin release, suggesting a potential site of action for -carbolines and similar hallucinogenic drugs.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

6-Methoxy-1, 2, 3, 4-tetrahydro-β-carboline effects on retinal serotonin

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References

Tetrahydronorharmane modulates the depolarisation-induced efflux of 5-hydroxytryptamine and dopamine and is released by high potassium concentration from rat brain slices.

Tetrahydronorharmane (THN) stimulates 5-hydroxytryptamine release from brain slices and decreases dopamine release, with high potassium concentrations releasing THN from rat brain slices.

UPTAKE OF [14C]ASPARTIC ACID AND [14C]GLUTAMIC ACID BY RETINAL SYNAPTOSOMAL FRACTIONS

High affinity uptake systems for aspartate and glutamate in rabbit retina support their involvement in neurotransmission.

β‐CARBOLINES: A TOOL FOR INVESTIGATING STRUCTURE‐ACTIVITY RELATIONSHIPS OF THE HIGH‐AFFINITY UPTAKE OF SEROTONIN, NORADRENALINE, DOPAMINE, GABA AND CHOLINE INTO A SYNAPTOSOME‐RICH FRACTION OF VARIOUS REGIONS FROM RAT BRAIN 1

CARBOLINES CAN BE USED TO EXPLORE STRUCTURE-ACTIVITY RELATIONSHIPS OF SEROTONIN, NORADRENALINE, DOPAMINE, GABA, and CHOLINE IN RAT BRAIN RESIDENCES.

Visual deprivation affects serotonin levels in the visual system

Visual deprivation significantly alters serotonin levels in the visual system, potentially affecting the development of visually guided behavior.

Chemical removal of indoleamine accumulating terminals in rabbit and goldfish retina.

Two consecutive days of indoleamine injections can effectively destroy indoleamine-accumulating retinal neurons in goldfish and rabbit retinas, but perikarya remain unaffected.

β-Carbolines in rat arcuate nucleus

-carbolines are present in the rat arcuate nucleus, with their presence affecting fluorescence intensity, and their treatment with certain drugs alters this effect.

Uptake of 5‐hydroxytryptamine by chick retina

Chick retina shows potential as a neurotransmitter, with a transport system for 5-hydroxytryptamine ( 5-HT) being demonstrated in vitro.

Monoamine oxidase inhibition in brain and liver produced by beta-carbolines: structure-activity relationships and substrate specificity.

Beta-carbolines effectively inhibit monoamine oxidase in brain and liver, with 6-Methoxy-1,2,3,4-tetrahydro--carboline being a relatively selective inhibitor of MAO type A.

Citations