6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: Reactivation for paraoxon-inhibited acetylcholinesterase.

doi:10.1016/j.ejmech.2019.111787

Paper

DOI: 10.1016/j.ejmech.2019.111787

6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: Reactivation for paraoxon-inhibited acetylcholinesterase.

Published 2019 · V. Semenov, I. Zueva, S. Lushchekina

European journal of medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

6-methyluracil derivatives linked with hydroxamic acid can reactivate organophosphate-inhibited acetylcholinesterase, potentially preventing neuron death and memory impairment in organophosphate-induced neurodegeneration.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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