7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.

doi:10.1016/j.bcp.2008.07.035

Paper

7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.

Published May 15, 2005 · O. N. Al Safarjalani, R. Rais, Y. A. Kim

Biochemical pharmacology

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Abstract

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In Vitro Study

Study Snapshot

7-deaza-6-benzylthioinosine analogues show potential as anti-toxoplasmic agents, with their effectiveness varying based on the substitutions on their phenyl rings.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.

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References

Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase.

7-deaza-6-benzylthioinosine analogues show potential as potent inhibitors of Toxoplasma gondii adenosine kinase, with substitutions at the para or meta positions enhancing binding affinity.

Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution.

The structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog demonstrates that ATP binding at millimolar concentrations does not require adenosine binding as a prerequisite.

6-Benzylthioinosine analogues: promising anti-toxoplasmic agents as inhibitors of the mammalian nucleoside transporter ENT1 (es).

Anti-toxoplasmic 6-benzylthioinosine analogues are effective inhibitors of mammalian nucleoside transporter ENT1 (es), selectively toxic to Toxoplasma gondii infected cells, and may protect host cells from toxic purine nu

6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.

6-benzylthioinosine analogues show potential as selective antitoxoplasmic agents, with their effectiveness varying based on the nature and position of their substituents on the phenyl ring.

Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase.

6-Benzylthioinosine analogues show potential as selectively toxic chemotherapeutic targets for treating toxoplasmosis, with substitution at the para position playing a crucial role in their activity.

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