A. Paul, S. Ladame
Oct 1, 2009
Citations
0
Influential Citations
23
Citations
Journal
Organic letters
Abstract
9-Amino substituted acridines undergo a reversible amine exchange reaction in water under near-physiological conditions via an unstable hemiaminal intermediate. This thermodynamically controlled reaction may have implications in understanding the mode of action of 9-aminoacridines in vivo and in the future design of drugs based on this scaffold.