Aborting solid tumours: a possible role for PGF2alpha.

doi:10.1016/0306-9877(80)90080-8

Paper

Aborting solid tumours: a possible role for PGF2alpha.

Published Feb 1, 1980 · R. Pearson

Medical hypotheses

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Abstract

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Study Snapshot

PGF2alpha may be an effective macrophage tumoricidal activator, potentially 'aborting' tumor cell mass through its abortifacient and parturition effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Aborting solid tumours: a possible role for PGF2alpha.

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References

Immunogenicity, parturition and the prostaglandins.

Maintenance and termination of pregnancy are contravening expressions of a maternal-fetal immunologic regulatory response, with prostaglandins playing a role in parturition and the immune response.

Tumor-mediated immunosuppression: prevention by inhibitors of prostaglandin synthesis.

Inhibitors of prostaglandin synthesis can block tumor-mediated immunosuppression, allowing normal antibody production in tumor-bearing mice treated with indomethacin.

Prostaglandins and the immune response.

Prostaglandins inhibit immune cell responsiveness and possess receptors, but their physiological role in immune cell regulation remains unresolved.

Peripheral plasma progesterone and utero-ovarian prostaglandin F concentrations in the cow around parturition.

Ovaries are the major source of progesterone in cows during late pregnancy, and prostaglandin F may be the luteolytic factor responsible for the sharp decline in plasma progesterone concentrations 48-36 hours before parturition.

MACROPHAGES IN SYNGENEIC ANIMAL TUMOURS

Macrophages are present in low or high concentrations in syngeneic animal fibrosarcomas, potentially indicating their role in tumor growth and metastasis.

Citations