Paper
Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones
Published Feb 1, 2018 · Isaac V. Cohen, E. Cirulli, Matthew W. Mitchell
EBioMedicine
Q1 SJR score
31
Citations
2
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Acetaminophen use, age, gender, and genetic variants can alter sulfated sex hormone levels, potentially impacting hormonal homeostasis and pain management.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
The role of sulfated steroid hormones in reproductive processes
Sulfated steroid hormones, despite their low membrane permeation, play a crucial role in reproductive processes by contributing to the regulation of steroid responsive organs through active import into specific cells.
2017·79citations·J. Geyer et al.·The Journal of Steroid Biochemistry and Molecular Biology
The Journal of Steroid Biochemistry and Molecular Biology
Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour.
Prenatal exposure to paracetamol/acetaminophen and its precursor aniline impairs male brain development and sexual behavior in adulthood, highlighting the need to limit its use during pregnancy.
2017·39citations·A. Hay-Schmidt et al.·Reproduction
Reproduction
Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites
Heterozygous rare variants in 17 genes play a significant role in determining abnormal blood metabolic phenotypes in adults, with some of these genes linked to inborn errors of metabolism or pediatric genetic conditions.
2017·341citations·T. Long et al.·Nature Genetics
Nature Genetics
Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity.
Acetaminophen can cause liver damage and brain toxicity at high doses, but low doses may have neuroprotective effects.
2016·285citations·C. Ghanem et al.·Pharmacological research
Pharmacological research
Analgesic use — prevalence, biomonitoring and endocrine and reproductive effects
High human exposure to paracetamol and salicylic acid can lead to endocrine disruption, altering reproductive function in both sexes.
2016·128citations·D. Kristensen et al.·Nature Reviews Endocrinology
Nature Reviews Endocrinology
Citations
Carbon-doped bimetallic oxide nanoflakes for simultaneous electrochemical analysis of ascorbic acid, uric acid, and acetaminophen in sweat.
Carbon-doped bimetallic oxide nanoflakes effectively detect ascorbic acid, uric acid, and acetaminophen in sweat, offering a one-stop detection system for cardiovascular and degenerative diseases.
2025·0citations·Fangfang Zhou et al.·Analytical methods : advancing methods and applications
Analytical methods : advancing methods and applications
A multibiomarker approach to investigate paracetamol effects in the reproduction regulatory axis of a male Neotropical catfish Rhamdia quelen
Environmental concentrations of paracetamol can cause alterations in the antioxidant system of male Rhamdia quelen catfish without significant changes in hormone levels or gene expression related to reproduction.
2023·0citations·M. Perussolo et al.·Acta Limnologica Brasiliensia
Acta Limnologica Brasiliensia
A REVIEW OF PARACETAMOL: MECHANISM OF ACTION AND THE EFFECTS ON SPERMATOGENESIS
Long-term high-dose paracetamol use can negatively impact sperm number, quality, and testicular morphology in both animals and humans.
2023·0citations·Thi Thu Hien Huynh et al.·Tạp chí Y Dược học Cần Thơ
Tạp chí Y Dược học Cần Thơ
Sıçanlarda Asetaminofen Kaynaklı Uterin ve Fallop Tüpleri Hasarına Karşı Eksozomların Kullanımı Üzerine Deneysel Bir Çalışma
Exosomes administered after acetaminophen toxicity can decrease cell death in the uterus and fallopian tubes without adverse effects.
2023·0citations·Enes Karaman et al.·Erciyes Üniversitesi Veteriner Fakültesi Dergisi
Erciyes Üniversitesi Veteriner Fakültesi Dergisi
Multi‐Omics Studies in Historically Excluded Populations: The Road to Equity
Multi-omics studies have improved our understanding of genetic associations, but more diverse datasets and cohorts are needed for equity in precision medicine and pharmacogenomics for historically excluded populations.
2022·9citations·Guang Yang et al.·Clinical Pharmacology & Therapeutics
Clinical Pharmacology & Therapeutics
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment
Paracetamol can disrupt reproductive hormone synthesis through hydrogen bonds, hydrophobic, and van der Waals interactions, potentially causing reproductive disorders.
2022·2citations·S. A. Abdi et al.·Toxicology Mechanisms and Methods
Toxicology Mechanisms and Methods
N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19
N-acetylcysteine (NAC) and other sulfur-donors can potentially prevent or reduce symptoms of COVID-19 by preserving the glycocalyx, which plays a crucial role in preventing and treating the disease.
2022·19citations·Heidi N du Preez et al.·Advances in Pharmacological and Pharmaceutical Sciences
Advances in Pharmacological and Pharmaceutical Sciences
CCDB: A database for exploring inter-chemical correlations in metabolomics and exposomics datasets
The Chemical Correlation Database (CCDB) is a user-friendly database that explores inter-chemical correlations in metabolomics and exposomics datasets, aiding in understanding biological and chemical relationships among metabolites and chemical exposures in the human body.
2022·5citations·D. Barupal et al.·Environment international
Environment international