A Trifluoroacetic Acid Catalyzed Domino Reaction as an Approach to Amino Acid Derived 2,3-Dihydro-1H-1,5-benzodiazepines

doi:10.1055/S-0033-1340837

Paper

A Trifluoroacetic Acid Catalyzed Domino Reaction as an Approach to Amino Acid Derived 2,3-Dihydro-1H-1,5-benzodiazepines

Published Mar 11, 2014 · Saurav Bera, P. S. Kandiyal, R. S. Ampapathi

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Abstract

Trifluoroacetic acid catalyzed condensation of aromatic amines with substituted benzaldehydes followed by intramolecular cyclization furnishes a highly effective synthesis of amino acid derived 2,3-dihydro-1H-1,5-benzodiazepines. The strategy provides an efficient access to a library of benzodiazepines that can be explored for potential pharmaceutical or biological activities.

Study Snapshot

Trifluoroacetic acid catalyzed Domino Reaction effectively synthesizes amino acid-derived 2,3-dihydro-1H-1,5-benzodiazepines, providing access to a library of potential pharmaceutical or biological activities.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

A Trifluoroacetic Acid Catalyzed Domino Reaction as an Approach to Amino Acid Derived 2,3-Dihydro-1H-1,5-benzodiazepines

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References

Citations

Quest for steroidomimetics: Amino acids derived steroidal and nonsteroidal architectures.

Chiral amino acids can be used to construct steroidal and non-steroidal architectures, offering new chiral chemical space and promising biological activity in hormonal related disorders.