The nicotinic acid receptor–a new mechanism for an old drug

doi:10.1016/S0140-6736(04)16359-9

Paper

DOI: 10.1016/S0140-6736(04)16359-9

The nicotinic acid receptor–a new mechanism for an old drug

Published Jun 5, 2004 · F. Karpe, K. Frayn

The Lancet

Q1 SJR score

181

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Rigorous Journal

Highly Cited

Study Snapshot

Nicotinic acid reduces non-esterified fatty acids and VLDL triglycerides, potentially improving insulin resistance, hyperlipidemia, and atherosclerosis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1111/J.0954-6820.1988.TB15891.X

Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid.

Combining clofibrate and nicotinic acid effectively reduces ischemic heart disease mortality by 36%, with the most pronounced effect in patients with high serum triglyceride levels.

2009·685citations·Lars A. Carlson et al.·Acta medica Scandinavica

Acta medica Scandinavica

DOI: 10.1016/J.BCP.2003.09.014

Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin.

Niacin stimulates key effectors of reverse cholesterol transport, potentially promoting atherosclerosis regression and combining it with statins for an overadditive clinical benefit.

2004·182citations·Tina Rubic et al.·Biochemical pharmacology

Biochemical pharmacology

DOI: 10.1042/BST0311115

The glucose-fatty acid cycle: a physiological perspective.

The glucose-fatty acid cycle is crucial for mammalian metabolism, with additional mechanisms reinforcing the importance of glucose and fat interactions.

2003·146citations·K. Frayn·Biochemical Society transactions

Biochemical Society transactions

DOI: 10.2337/DIABETES.52.11.2748

Contribution of elevated free fatty acid levels to the lack of glucose effectiveness in type 2 diabetes.

Elevated free fatty acid levels contribute significantly to the loss of glucose effectiveness in poorly controlled type 2 diabetes, affecting glucose suppression and uptake responses to hyperglycemia.

2003·82citations·M. Hawkins et al.·Diabetes

Diabetes

DOI: 10.1016/S0165-6147(03)00132-9

Do regional differences in adipocyte biology provide new pathophysiological insights?

Regional differences in adipocyte biology may explain the different risk factors for obesity in 'apples' and 'pears,' with adipocytes from visceral and subcutaneous deposits showing different functions and responsiveness.

2003·286citations·M. Lafontan et al.·Trends in pharmacological sciences

Trends in pharmacological sciences

DOI: 10.1074/JBC.M210695200

Molecular Identification of High and Low Affinity Receptors for Nicotinic Acid*

HM74A, a high affinity receptor for nicotinic acid, may facilitate the discovery of superior drug molecules to treat dyslipidemia.

2003·523citations·A. Wise et al.·The Journal of Biological Chemistry

The Journal of Biological Chemistry

DOI: 10.1038/nm824

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

PUMA-G and HM74 receptors mediate the anti-lipolytic and lipid-lowering effects of nicotinic acid, potentially aiding in the development of new drugs for treating dyslipidemia.

2003·756citations·S. Tunaru et al.·Nature Medicine

Nature Medicine

DOI: 10.1007/s00125-002-0964-9

Interaction between specific fatty acids, GLP-1 and insulin secretion in humans

Increasing plasma NEFA concentrations through oral fat feeding with heparin infusion increases glucose-stimulated insulin secretion, with monounsaturated fatty acids having the greatest effect and also increasing GLP-1 more than saturated fatty acids.

2002·102citations·Beysen C. et al.·Diabetologia

Diabetologia

DOI: 10.1002/1521-4141(200112)31:12<3714::AID-IMMU3714>3.0.CO;2-1

PUMA‐G, an IFN‐γ‐inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily

PUMA-G is a novel IFN-inducible gene in macrophages, potentially playing a role in macrophage functions and innate immunity.

2001·130citations·Annette Schaub et al.·European Journal of Immunology

European Journal of Immunology

Citations

DOI: 10.1016/j.jct.2023.107084

Solubility and thermodynamic parameters of nicotinic acid in different solvents

DMSO has the highest nicotinic acid solubility, making it useful for crystallization and encapsulation operations.

2023·9citations·M. Silveira et al.·The Journal of Chemical Thermodynamics

The Journal of Chemical Thermodynamics

DOI: 10.1007/s10973-022-11300-z

Calorimetric study of the thermodynamics of iron (III) complexation with nicotinic acid in aqueous ethanol

Adding ethanol to water significantly increases the exothermicity of iron (III) complexation with nicotinic acid, with the change in enthalpy caused by changes in nicotinic acid solvation state and desolvation of reaction products in concentrated solutions.

2022·1citation·Natalia N. Kuranova et al.·Journal of Thermal Analysis and Calorimetry

Journal of Thermal Analysis and Calorimetry

DOI: 10.31989/ffhd.v12i1.874

Correction of metabolic disturbances by functional food compositions in experimental obesity in CD-1 and agouti-yellow mice

Feeding mice with composition 2 improved metabolic disturbances and histological pictures of studied organs and tissues in experimental obesity.

2022·1citation·P. Lebedev et al.·Functional Foods in Health and Disease

Functional Foods in Health and Disease

DOI: 10.21203/rs.3.rs-1199938/v1

Nicotinamide riboside promotes Mfn2-mediated mitochondrial fusion in diabetic hearts through the SIRT1-PGC1α-PPARα pathway.

Nicotinamide riboside supplementation promotes mitochondrial fusion in diabetic hearts, potentially delaying cardiac complications in diabetes patients.

2021·42citations·Lang Hu et al.·Free radical biology & medicine

Free radical biology & medicine

DOI: 10.1007/s11172-021-3235-y

Sorption of pyridine-3-carboxylic acid by the Dowex-50 sulfonic cation-exchange resin in the NiII and CuII forms

The Dowex-50 sulfonic cation-exchange resin effectively concentrates pyridine-3-carboxylic acid and divalent transition metal cations, making it a useful container for drugs based on these compounds.

2021·1citation·H. Altshuler et al.·Russian Chemical Bulletin

Russian Chemical Bulletin