T. Miyamoto, H. Egawa, J. Matsumoto
Jun 25, 1987
Citations
0
Influential Citations
24
Citations
Journal
Chemical & pharmaceutical bulletin
Abstract
An alternative synthesis of enoxacin, a 1, 8-naphthyridine antibacterial agent, was developed. The present method involves 1, 8-naphthyridine ring construction by the Dieckmann type cyclization of ethyl 5-fluoronicotinate having a 2-ethoxycarbonylethylamino moiety at C-2. This nicotinate was prepared in 7 steps from ethyl fluoroacetate via ethyl 2, 6-dichloro-5-fluoronicotinate.