The antiandrogenic action of 4-androsten-3-one-17 beta-carboxylic acid and its methyl ester on hamster flank organ.

doi:10.1210/ENDO-92-4-1216

Paper

The antiandrogenic action of 4-androsten-3-one-17 beta-carboxylic acid and its methyl ester on hamster flank organ.

Published Apr 1, 1973 · W. Voigt, S. Hsia

Endocrinology

Q1 SJR score

86

Citations

2

Influential Citations

Full textSemantic Scholar

Abstract

4–Androsten–3–one–17β–carboxylic acid (17βC), an inhibitor of testosterone 5α–reductase, as discovered in our enzymic studies of human skin, was tested for its antiandrogenic potency in the hamster flank organ, which is an androgen—dependent sebaceous structure. The organ in the female animals enlarged in size and increased in pigmentation after topical application of testosterone propionate, 4 μg per day for 2 to 3 weeks. This response was completely inhibited by the concomitant application of 17βC or its methyl ester (400 μg per day). Topical application of 5α–dihydrotestosterone (DHT, 4 jig per day) also caused the enlargement of the flank organ, but the action of DHT was not inhibited by 17βC. Incubation of [14C] testosterone with homogenates of the flank organ produced DHT and androstane–3α,17β–diol (ADIOL) as the major metabolites. The formation of these two 5asteroids was inhibited by 17βC added in the incubation medium. These results indicate that 17βC is an antiandrogen, which acts by inhibition ...

Non-RCT

Animal Study

Highly Cited

Study Snapshot

17-C effectively inhibits testosterone-induced enlargement and pigmentation in hamster flank organs, acting as an antiandrogen by inhibiting testosterone 5-reductase activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

The antiandrogenic action of 4-androsten-3-one-17 beta-carboxylic acid and its methyl ester on hamster flank organ.

Sign up to use Study Snapshot

References

Citations

A full conformational characterization of antiandrogen cortexolone-17α-propionate and related compounds through theoretical calculations and nuclear magnetic resonance spectroscopy

Cortexolone-17-propionate shows good conformational characterization, but functional groups in the skeleton drive the individual biological profiles of these compounds.

Molecular interactions of natural and synthetic steroids in female hamsters' flank organs.

Different steroids regulate lipid metabolism in female hamsters' flank organs through different mechanisms of action.

Disorders of the Sebaceous Glands

Sebaceous gland disorders include inflammation, nevoid, benign, and malignant processes, leading to a wide spectrum of skin conditions.

Novel C-6 substituted and unsubstituted pregnane derivatives as 5α-reductase inhibitors and their effect on hamster flank organs diameter size

Compounds 12a-12d, 13 and 15 show antiandrogenic effects in hamsters, but their effect is not statistically significant compared to finasteride.

Sexual autophagic differences in the androgen-dependent flank organ of Syrian hamsters.

Macroautophagy, not apoptosis, is the main mechanism by which the flank organ of Syrian hamsters responds to androgen, with females showing higher autophagy activity.