[Action of 5-bromouracil and its nucleosides on the morphogenesis of the cuttings of etiolated tomato seedlings].

doi:10.1007/BF00389207

Paper

[Action of 5-bromouracil and its nucleosides on the morphogenesis of the cuttings of etiolated tomato seedlings].

Published Sep 1, 1971 · A. Guillot

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Abstract

1. 5-Bromouracil inhibits the growth of the hypocotyl and the rhizogenesis in the cuttings of etiolated tomato seedlings only at high concentrations. 5-Bromouridine is inactive, but 5-bromodeoxyuridine strongly inhibits both phenomena. 2. The inhibition induced by 5-bromouracil cannot be reversed by thymine, deoxythymidine, uracil, uidine or β-alanine, a catabolic product of uracil. 3. Deoxythymidine is the one pyrimidine nucleoside which reverses the inhibition of growth and rhizogenesis brought about by 5-bromodeoxyuridine. 4. Deoxycytidine enhances the inhibition of rhizogenesis caused by 5-bromodeoxyuridine. Such an effect on the growth of the hypocotyl is not observed. 5. Taking into consideration the data in the literature, it is concluded: a)5-bromouracil can act in several ways which possibly differ according to the plant species: in some instances (as in the case described here), it seems to act by a mechanism unconnected with the metabolism of pyrimidine nucleic bases: b) 5-bromodeoxyuridine is a specific antimetabolite of deoxythymidine, but other metabolic interactions exist between 5-bromodeoxyuridine and deoxycytidine, each of the latter substances probably acting as a modifier of the metabolism of the other.

Study Snapshot

5-bromouracil inhibits tomato seedling growth and rhizogenesis, with deoxythymidine reverse-reversing its effects, and 5-bromodeoxyuridine acting as a specific antimetabolite of deoxythymidine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

[Action of 5-bromouracil and its nucleosides on the morphogenesis of the cuttings of etiolated tomato seedlings].

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References

Purification and comparative properties of a pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus.

Bacillus stearothermophilus pyrimidine nucleoside phosphorylase has unique properties, including molecular weight, substrate specificity, thermostability, and induction properties compared to Bacillus subtilis and Escherichia coli nucleoside phosphorylases

Pyrimidine deoxyribonucleoside phosphorylase. I. Substrate inhibition by thymine.

Thymidine phosphorylase is inhibited by high concentrations of thymine and modified by urea or low pH, with immediate reversible effects.

Pyrimidine nucleoside phosphorylases of rat liver. Separation by ion exchange chromatography and studies of the effect of cytidine or uridine administration.

Uridine phosphorylases in rat liver increase their specific activities 3-fold when injected with uridine, while cytidine increases their specific activities 2-fold, with thymidine phosphorylase showing no change.

Thymidine and Thymine Incorporation into Deoxyribonucleic Acid: Inhibition and Repression by Uridine of Thymidine Phosphorylase of Escherichia coli

Uridine greatly increases thymidine incorporation into DNA in Escherichia coli by inhibiting thymidine phosphorylase and preventing degradation of thymidine to thymine, suggesting thymine utilization in wild-type cells.

Mechanism of regulation of deoxythymidine kinase of Escherichia coli. I. Effect of regulatory deoxynucleotides on the state of aggregation of the enzyme.

Dimerization is an essential change involved in both inhibitory and activating regulation of Escherichia coli deoxythymidine kinase by deoxynucleotides, with activators producing a marked increase in the sedimentation rate.

Studies of bromouracil deoxyriboside substitution in DNA of bean roots (Vicia faba).

Bean roots grown in BUdR solution produce partially substituted DNA, with no fully substituted chain produced under these conditions.

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