Paper
The lipolytic action of fructose-1-6-diphosphate.
Published Aug 1, 1968 · C. Chlouverakis
Metabolism: clinical and experimental
Q1 SJR score
35
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Fructose-1-6-diphosphate significantly stimulates lipolysis in adipose tissue, suggesting a specific activating effect on the lipolytic enzyme system.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Factors affecting the inhibitory action of insulin on lipolysis in a glucose-free medium.
Insulin partially inhibits lipolysis in a glucose-free medium, independent of adrenalin and reserpine, and its inhibitory effect is not abolished by 2-deoxy-D-glucose or 3-methylglucose.
1967·19citations·C. Chlouverakis·Endocrinology
Endocrinology
The action of glucose on lipolysis.
Glucose stimulates lipolysis through intracellular metabolism, accelerating the cycle of glycerol-FFA release, but its effect is mild and variable compared to adipokinetic hormones.
1967·30citations·C. Chlouverakis·Metabolism: clinical and experimental
Metabolism: clinical and experimental
Evidence for a role of adenosine 3',5'-monophosphate in adipose tissue lipolysis.
Cyclic 3',5'-AMP plays a key role in regulating fat cell lipolysis, with both norepinephrine and adenosine 3',5'-monophosphate acting through this compound.
1966·79citations·B. Weiss et al.·Biochemical pharmacology
Biochemical pharmacology
Citrate and the regulation of adipose-tissue phosphofructokinase.
Citrate inhibits phosphofructokinase in adipose tissue, while ADP, AMP, 3',5'-(cyclic)-AMP, phosphate, and sulphate activate it, suggesting a role in glycolysis and lipogenesis.
1966·70citations·R. Denton et al.·The Biochemical journal
The Biochemical journal
Effects of serotonin (5-hydroxytryptamine) and adenosine 3',5'-phosphate on phosphofructokinase from the liver fluke Fasciola hepatica.
Serotonin and adenosine 3',5'-phosphate increase the activity of phosphofructokinase in the liver fluke Fasciola hepatica, potentially mediated via cyclic nucleotide pathways.
1962·172citations·T. Mansour et al.·The Journal of biological chemistry
The Journal of biological chemistry
Citations
Fructose‐1,6‐bisphosphate reverses hypotensive effect caused by L‐kynurenine in Wistar male rats
Fructose-1,6-bisphosphate (FBP) reverses the hypotensive effect caused by L-kynurenine in Wistar male rats, suggesting potential therapeutic applications for inflammation-related hypotension.
2024·0citations·A. V. Catarina et al.·Physiological Reports
Physiological Reports
Fructose-1,6-bisphosphate preserves glucose metabolism integrity and reduces reactive oxygen species in the brain during experimental sepsis
FBP treatment preserves glucose metabolism and reduces reactive oxygen species in the brain during experimental sepsis, suggesting it may be a potential candidate for treating sepsis-associated encephalopathy.
2018·15citations·A. V. Catarina et al.·Brain Research
Brain Research
Fructose-1,6-Bisphosphate and Fructose-2,6-Bisphosphate do not Influence Brain Carbohydrate or High-energy Phosphate Metabolism in a Rat Model of Forebrain Ischemia
Phosphorylated fructose compounds do not influence brain carbohydrate or high-energy phosphate metabolism during forebrain ischemia, suggesting other mechanisms are responsible for their neuronal protection.
2009·7citations·R. E. Hofer et al.·Journal of Neurosurgical Anesthesiology
Journal of Neurosurgical Anesthesiology
Activation of the neuroprotective ERK signaling pathway by fructose-1,6-bisphosphate during hypoxia involves intracellular Ca2+ and phospholipase C
FBP protects neurons during hypoxia by activating the PLC signaling pathway, increasing intracellular calcium levels, and increasing the activity of the MEK/ERK signaling pathway.
2002·56citations·C. Fahlman et al.·Brain Research
Brain Research
Neuroprotection and intracellular Ca2+ modulation with fructose-1,6-bisphosphate during in vitro hypoxia–ischemia involves phospholipase C-dependent signaling
FBP protects neurons and stabilizes intracellular calcium levels during hypoxia by activating neuroprotective signaling pathways that modulate calcium homeostasis.
2001·39citations·P. Donohoe et al.·Brain Research
Brain Research
Fructose-1,6-diphosphate fails to limit early myocardial infarction size in a canine model.
FDP given after coronary occlusion in dogs did not limit early myocardial infarct size in this model.
1993·6citations·M. Angelos et al.·Annals of emergency medicine
Annals of emergency medicine
Beneficial effects of fructose-1,6-diphosphate infusion on liver regeneration after ischemie liver injury
FDP infusion has cytoprotective and hepatotrophic effects on liver with ischemic injury, and divided dose administration is more effective than bolus doses in decreasing damage after ischemic and reperfusion injury.
1991·5citations·T. Nakai et al.·Gastroenterologia Japonica
Gastroenterologia Japonica
Effect of exogenous fructose-1,6-bisphosphate on glycolysis in the isolated perfused rat heart.
Fructose-1,6-bisphosphate reduces glycolytic rate and oxygen consumption in isolated perfused rat hearts, suggesting its cardioprotective action is related to substrate effect and decreased adenosine triphosphate consumption.
1991·21citations·E. Nuutinen et al.·American heart journal
American heart journal