The action and interaction of diphenhydramine (Benadryl) hydrochloride at the neuromuscular junction.

doi:10.1016/0014-2999(73)90008-3

Paper

The action and interaction of diphenhydramine (Benadryl) hydrochloride at the neuromuscular junction.

Published May 1, 1973 · A. Abdel-aziz, N. Bakry

European journal of pharmacology

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8

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Abstract

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In Vitro Study

Study Snapshot

Diphenhydramine (Benadryl) hydrochloride can amplify muscle twitches and block neuromuscular transmission at different concentrations, with potential interactions with other drugs.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The action and interaction of diphenhydramine (Benadryl) hydrochloride at the neuromuscular junction.

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References

The Pharmacological Basis of Therapeutics

This comprehensive pharmacology book provides up-to-date reviews on drug use, including historical background, structure-activity relationships, dosages, side effects, and therapeutic uses.

The effects of local anesthetics on motor nerve terminals.

Local anesthetics selectively depress motor nerve terminals, affecting muscle contraction and twitching patterns without affecting single twitches.

ACTION OF SEVERAL ANTI-HISTAMINICS ON THE ISOLATED RAT PHRENIC-DIAPHRAGM PREPARATION.

Anti-histaminics show neuromuscular blocking properties, as demonstrated by their action on a rat phrenic-diaphragm preparation, suggesting potential applications in treating neuromuscular blockade.

THE ACTION OF PROCAINE AT THE NEUROMUSCULAR JUNCTION

Procaine selectively reduces neostigmine-induced twitching and acetylcholine release in the neuromuscular junction, likely due to its local anesthetic effect on fine motor nerve terminals.

The action of hypnotic drugs on frog skeletal muscle.

Barbiturates can augment the "twitch" of isolated frog muscles when excited by motor nerves, potentially affecting their neuro-muscular junction responses.

Citations