Paper
The action of (S)-alpha-chlorohydrin and 6-chloro-6-deoxyglucose on the metabolism of guinea pig spermatozoa.
Published Sep 1, 1984 · A. Jones, S. A. Ford
Contraception
Q1 SJR score
22
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
(S)--chlorohydrin and 6-chloro-6-deoxyglucose inhibit glyceraldehyde-phosphate dehydrogenase in guinea pig spermatozoa, likely due to the common metabolite (S)-3-
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
The effect of α-chlorohydrin on the oxidation of fructose by rabbit spermatozoa in vitro
(R,S)--chlorohydrin inhibits the oxidative metabolism of fructose in rabbit spermatozoa, potentially explaining its ineffectiveness as an antifertility agent in male rabbits.
1983·7citations·S. A. Ford et al.·Contraception
Contraception
The effect of the isomers of α-chlorohydrin and racemic β-chlorolactate on the rat kidney
The (S)-isomers of -chlorohydrin and 3-amino-1-chloropropan-2-ol have no detrimental effect on the kidney, while the (R)-isomers cause renal toxicity through inhibition of oxidative metabolism.
1982·31citations·K. Porter et al.·Chemico-Biological Interactions
Chemico-Biological Interactions
Activities of various 6-chloro-6-deoxysugars and (S) alpha-chlorohydrin in producing spermatocoeles in rats and paralysis in mice and in inhibiting glucose metabolism in bull spermatozoa in vitro.
Alpha-chlorohydrin effectively inhibits glucose metabolism in bull spermatozoa, while other compounds produce spermatocoeles and cause neurotoxicity in mice, suggesting different metabolites cause antifertility and neurotoxic effects.
1982·36citations·W. Ford et al.·Journal of reproduction and fertility
Journal of reproduction and fertility
The effect of high doses of 6-chloro-6-deoxyglucose on the rat.
High doses of 6-chloro-6-deoxyglucose can cause spermatocoeles, lower serum triglyceride content, and cause weight loss in male rats, but have no effect on female rats.
1981·23citations·W. Ford et al.·Contraception
Contraception
Effects of 6-chloro-6-deoxysugars on glucose oxidation in rat spermatozoa.
6-chloro-6-deoxysugars inhibit glucose oxidation in rat spermatozoa, potentially affecting fertility and sperm motility.
1981·23citations·W. Ford et al.·Journal of reproduction and fertility
Journal of reproduction and fertility
Citations
Determination of 3-MCPD esters in edible oil – methods of analysis and comparability of results
The proficiency test showed that 56% of food control laboratories performed satisfactorily in determining 3-MCPD esters in palm oil, and 85% for spiked extra virgin olive oil, but direct transesterification without glycidol esters removal may lead to strong positive bias.
2011·15citations·L. Karásek et al.·European Journal of Lipid Science and Technology
European Journal of Lipid Science and Technology
Structural diversity of dietary fatty esters of chloropropanols and related substances
3-MCPD esters in food are not isolated, and their safety requires considering other related molecules for risk assessment and mitigation.
2011·37citations·W. Seefelder et al.·European Journal of Lipid Science and Technology
European Journal of Lipid Science and Technology
Fatty acid esters of chloropropanols and related compounds in food: Toxicological aspects
Fatty acid esters of chloropropanols are present in various foods and food ingredients, but their human health significance remains unclear due to a lack of toxicological and exposure data.
2011·92citations·B. Schilter et al.·European Journal of Lipid Science and Technology
European Journal of Lipid Science and Technology
The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation.
3-chloropropanediol's neurotoxicity is not due to energy deprivation, but rather selective bioactivation and disruption of redox state.
2007·26citations·J. Skamarauskas et al.·Toxicology
Toxicology
Occurrence of 3-chloro-propane-1,2-diol (3-MCPD) and related compounds in foods: a review
3-MCPD is found in cereals, meat, and dairy products, but its toxicology and in-vivo formation remain unclear.
2002·145citations·C. Hamlet et al.·Food Additives & Contaminants
Food Additives & Contaminants
In vitro inhibition of rat cauda epididymal sperm glycolytic enzymes by ornidazole, alpha-chlorohydrin and 1-chloro-3-hydroxypropanone.
CHOP and related ketals may be more effective inhibitors of sperm glycolysis than ACH, potentially aiding in the development of antiglycolytic post-testicular contraceptives.
2000·17citations·W. Bone et al.·International journal of andrology
International journal of andrology
Inhibition of glycolysis in boar spermatozoa by 1,6-dichloro-1,6-dideoxy-D-fructose.
1,6-dichloro-1,6-dideoxy-D-fructose inhibits glycolysis in boar spermatozoa by converting it into chloro-trioses, which then inhibit glyceraldehyde-3-phosphate dehydrogenase,
1995·11citations·A. Jones et al.·Biochimica et biophysica acta
Biochimica et biophysica acta
Hexose-6-kinases in germinating honey locust cotyledons: substrate specificity of D-fructo-6-kinase.
The particulate hexokinase in germinating honey locust cotyledons catalyzes the phosphorylation of released d-mannose, while the fructo-kinase has limited substrate specificity.
1994·9citations·D. K. Myers et al.·Phytochemistry
Phytochemistry