The cardiovascular actions 1-(3-aminophenyl)-2-aminoethanol and related compounds.

Paper

The cardiovascular actions 1-(3-aminophenyl)-2-aminoethanol and related compounds.

Published Apr 1, 1952 · A. M. Lands

The Journal of pharmacology and experimental therapeutics

Q2 SJR score

5

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0

Influential Citations

Semantic Scholar

Abstract

The results obtained in this investigation have shown 1-(3-aminophenyl)-2-aminoethanol and the corresponding -2-methylamino and -2-ethylamino analogs to be effective pressor agents. The primary amine is most pressor and this activity is diminished by alkyl substitution. 1-(3-Aminophenyl)-2-isopropylaminoethanol is depressor. The substitution of the ring with a m -amino group causes a small increase in pressor potency; with a m -hydroxyl group a large increase in pressor potency. Neither the pressor amine, 1-(3-aminophenyl)-2-aminoethanol, nor its depressor homolog, 1-(3-aminophenyl)-2-isopropylaminoethanol, were effective in preventing bronchoconstriction in guinea pigs exposed to a histamine aerosol. The acute toxicity (i.p. and i.v. in mice) appears to be less than that of the corresponding unsubstituted and m -hydroxy analogs.

Non-RCT

Animal Study

Study Snapshot

1-(3-aminophenyl)-2-aminoethanol and its related compounds are effective pressor agents, but do not prevent bronchoconstriction and have less acute toxicity than unsubstituted and m-hydroxy analogs.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The cardiovascular actions 1-(3-aminophenyl)-2-aminoethanol and related compounds.

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References

Citations

Activities of octopamine and synephrine stereoisomers on α‐adrenoceptors

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β‐Adrenergic activities of octopamine and synephrine stereoisomers on guinea‐pig atria and trachea

The ()-forms of m and poctopamine and ()-forms of m and psynephrine are 100-fold less active than noradrenaline on 1 adrenoceptors, and their (+

Isomeric octopamines: their occurrence and functions

Isomeric octopamines, p-, m-, and o-octopamine, are found in mammals, with their distribution and possible functions still inconclusive.

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