Paper
The Hypnotic Actions of the Fatty Acid Amide, Oleamide
Published Nov 1, 2001 · W. Mendelson, A. Basile
Neuropsychopharmacology
Q1 SJR score
62
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Oleamide induces sleep in rats and mice, with its mechanism of action involving cannabinergic pathways and potential for clinical use as hypnotics.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
The hypnotic actions of oleamide are blocked by a cannabinoid receptor antagonist.
Oleamide's sleep-inducing effects are blocked by the CB1 receptor antagonist SR141716, suggesting that it involves interactions with the CB1 receptor system.
1999·55citations·Wallace B. Mendelson et al.·Neuroreport
Neuroreport
Characterization of the hypnotic properties of oleamide.
Oleamide effectively induces sleep and has potential as a sleep-inducing agent, with potential links to serotonergic and GABAergic neurotransmission.
1999·82citations·A. Basile et al.·Neuroreport
Neuroreport
Maintenance of Recombinant Type A γ-Aminobutyric Acid Receptor Function: Role of Protein Tyrosine Phosphorylation and Calcineurin
GABAA receptor function is maintained by protein phosphorylation at a tyrosine kinase-dependent site and a distinct unidentified site, which is dephosphorylated by calcineurin.
1998·65citations·Renqi Huang et al.·The Journal of Pharmacology and Experimental Therapeutics
The Journal of Pharmacology and Experimental Therapeutics
Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration.
Oleamide, a potential sleep-inducing substance, increases benzodiazepine-sensitive gamma-aminobutyric acid receptor function but does not alter minimum alveolar anesthetic concentration in rats.
1998·55citations·Yost Cs et al.·Anesthesia & Analgesia
Anesthesia & Analgesia
Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide.
Oleamide selectively potentiates 5-HT2A serotonin receptors, with its structural features requiring precise positioning and stereochemistry, while 5-HT1A receptors are more tolerant and tolerate a wider range of structural modifications.
1998·94citations·D. Boger et al.·Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Citations
Proteomic profiling of oleamide-mediated polarization in a primary human monocyte-derived tumor-associated macrophages (TAMs) model: a functional analysis
Oleamide promotes antitumor effects by suppressing protumor M2-like tumor-associated macrophage phenotypes, potentially offering insights into cancer immunotherapy approaches.
2024·0citations·Prapakorn Wisitpongpun et al.·PeerJ
PeerJ
Serum Metabolomics Analysis Revealed Metabolic Pathways Related to AECOPD Complicated with Anxiety and Depression
Serum metabolomics analysis reveals key metabolites and metabolic pathways disturbed in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with anxiety and depression.
2024·0citations·Jing Ye et al.·International Journal of Chronic Obstructive Pulmonary Disease
International Journal of Chronic Obstructive Pulmonary Disease
Wild Mushrooms as a Source of Bioactive Compounds and Their Antioxidant Properties—Preliminary Studies
Wild mushrooms contain various bioactive compounds, polyphenols, minerals, and antioxidant properties, making them potential materials for health-promoting foods, nutraceuticals, and dietary supplements.
2024·0citations·I. Bolesławska et al.·Foods
Foods
Receptor and metabolic insights on the ability of caffeine to prevent alcohol-induced stimulation of mesolimbic dopamine transmission
Caffeine and A2AR antagonists can potentially prevent alcohol-induced stimulation of mesolimbic dopamine transmission, potentially aiding in preventive/therapeutic strategies for alcohol use disorder.
2024·0citations·Riccardo Maccioni et al.·Research Square
Research Square
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey
Allosteric modulators of serotonin receptors show potential as safer antiobesity agents due to their less conserved, more specific binding sites.
2024·2citations·L. Brunetti et al.·Pharmaceuticals
Pharmaceuticals
A UHPLC–MS/MS method for determination of N-acylethanolamines in cerebrospinal fluid
This study developed a UHPLC-MS/MS method for quantitative analysis of endocannabinoids in cerebrospinal fluid, enabling the identification and estimation of their concentrations in healthy individuals.
2024·0citations·Visolakhon Ismoilova et al.·bioRxiv
bioRxiv
Cannabinoids: Emerging sleep modulator.
Cannabinoids play a role in modulating sleep, with selective alteration of CB 2 receptors potentially treating sleep disorders.
2023·6citations·Zhen Xuen Brandon Low et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Looking back at a life in sleep research—and some thoughts for the future
The medial preoptic area may be a common site for sleep-promoting effects of various agents, and future research should consider beta-carbolines and the endocannabinoid system for treating sleep/wake disorders.
2022·1citation·W. Mendelson·Sleep Advances: A Journal of the Sleep Research Society
Sleep Advances: A Journal of the Sleep Research Society