Biological Actions of Leukotrienes: State of the Art Lecture

doi:10.1161/01.HYP.8.6_PT_2.II44

Paper

Biological Actions of Leukotrienes: State of the Art Lecture

Published Jun 1, 1986 · A. Ford-hutchinson, G. Letts

Hypertension

Q1 SJR score

20

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0

Influential Citations

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Abstract

Leukotrienes are novel mediators derived from arachidonic acid through the 5-lipoxygenase enzyme system. Leukotriene B4 has potent effects on leukocyte function and in vivo induces leukocyte accumulation and changes in vascular permeability and modulates pain responses. Peptidolipid leukotrienes are potent smooth muscle-contracting agents. They may have important cardiovascular actions through mechanisms involving either vasoconstriction or indirect vasodilatation. Evidence for leukotriene production has been found in subjects with allergic conditions and psoriasis, indicating a putative role for these substances in human disease.

Study Snapshot

Leukotrienes play a role in leukocyte function, vascular permeability, pain responses, and may play a role in allergic conditions and psoriasis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Biological Actions of Leukotrienes: State of the Art Lecture

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References

The binding of leukotriene C4 and leukotriene D4 to membranes of a smooth muscle cell line (BC3H1) and evidence that leukotriene induced contraction in these cells is mediated by thromboxane, protein and RNA syntheses.

Leukotriene C4 and D4 induce contraction in smooth muscle cells through thromboxane, protein, and RNA syntheses, with the rate-limiting step being the formation of free arachidonic acid.

Leukotriene B4 and 12-hydroxyeicosatetraenoic acid stimulate epidermal proliferation in vivo in the guinea pig.

Leukotriene B4 and 12-hydroxyeicosatetraenoic acid stimulate epidermal proliferation in guinea pigs, with a dose-dependent effect and a stereospecific effect.

Leukotriene A5 is a substrate and an inhibitor of rat and human neutrophil LTA4 hydrolase.

Leukotriene A5 is both a substrate and inhibitor of rat and human neutrophil LTA4 hydrolase, with inhibition potentially involving covalent coupling of leukotriene A5 to the LTA4 hydrolase.

Leukotriene A3. A poor substrate but a potent inhibitor of rat and human neutrophil leukotriene A4 hydrolase.

Leukotriene A3 is a potent inhibitor of leukotriene B4 production by rat neutrophils and human neutrophils, blocking the binding of leukotriene A4 to the enzyme.

Unique coronary vasodilator induction by leukotriene D4.

Leukotriene D4 induces a unique coronary vasodilator factor, which may account for the escape from LTD4-induced coronary constriction.

Citations

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Macrophage immunoregulatory pathways in tuberculosis.

Macrophage responses to tuberculosis infection vary due to differences in strains and macrophage types, with alveolar macrophages potentially delaying optimal immune responses.

Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders

Cyclooxygenases, lipoxygenases, and epoxygenases play crucial roles in brain function and neuroinflammation in neurological disorders like ischemia, epilepsy, and Alzheimer's disease.

Role of sodium in intracellular calcium elevation and leukotriene B4 formation by receptor-mediated activation of human neutrophils.

Intracellular sodium concentration plays a crucial role in leukotriene B4 generation and intracellular calcium elevation in human neutrophils, unrelated to calcium influx through the Na(+)/Ca(2+) exchanger.