Toxic actions of senaetnine, a new pyrrolizidine-type alkaloid, in rats.

doi:10.1016/0378-4274(87)90014-2

Paper

Toxic actions of senaetnine, a new pyrrolizidine-type alkaloid, in rats.

Published Oct 1, 1987 · A. Mattocks, E. Driver

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Senaetnine, a new alkaloid from Senecio, shows moderate tissue injury without metabolic activation, suggesting the need for further testing for chronic toxicity and carcinogenicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Toxic actions of senaetnine, a new pyrrolizidine-type alkaloid, in rats.

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References

Further pyrrolizidine alkaloids and furoeremophilanes from Senecio species

New pyrrolizidine alkaloids and furoeremophilanes were identified in 17 Senecio species, with some novel compounds and improved spectroscopic methods.

A comparison of the pneumotoxicity of some pyrrolic esters and similar compounds analogous to pyrrolizidine alkaloid metabolites, given intravenously to rats.

Pyrolic esters and similar compounds with similar chemical properties can cause lung damage and death in rats, with toxicity mainly dependent on chemical reactivity rather than molecular structure.

Estimated intakes of pyrrolizidine alkaloids by humans. A comparison with dose rates causing tumors in rats.

Pyrrolizidine alkaloids, found in plants, are carcinogenic in rats but have not been linked to human tumors.

Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues.

Repeated topical doses of dehydromonocrotaline and croton oil can cause skin cancer in mice, with 2,3-bistrimethylace-toxymethyl-1-methylpyrrole being particularly carcinogenic.

Dehydroretronecine-induced skin tumors in mice.

Dehydroretronecine is a proximate carcinogen that causes a high incidence of skin tumors in mice at the site of injection or topical application.

Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure.

Pyrolizidine alkaloids and derivatives show varying hepatotoxicity, with some showing acute and chronic lung lesions, and their structure activity requirements for both hepatotoxicity and pneumotoxicity are the same.

Acute hepatotoxicity and pyrrolic metabolites in rats dosed with pyrrolizidine alkaloids.

The acute hepatotoxicity of pyrrolizidine alkaloids in rats is linked to the amounts of pyrrolic metabolites in their livers, with sex, diet, and predosing with compounds affecting hepatic microsomal enzymes affecting toxicity.

Estimation of metabolites of pyrrolizidine alkaloids in animal tissues.

This study presents methods for estimating pyrrole and N-oxide metabolites in animal tissues from pyrrolizidine alkaloids, using ascorbic acid, mercuric chloride, and aqueous ferrous complexes.

Lesions in the liver and lungs of rats given pyrrole derivatives of pyrrolizidine alkaloids

Pyrole derivatives of pyrrolizidine alkaloids may play a role in initiating liver and lung lesions in rats, potentially causing acute liver damage.

Citations