Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects

doi:10.1007/BF02806010

Paper

Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects

Published 2008 · A. R. Rigon, R. Takahashi

Psychopharmacology

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Abstract

The present study evaluated the effects of dimethocaine and procaine, esteratic local anesthetics, on locomotor activity, conditioned place preference and on the elevated plus-maze test of anxiety in mice, behavioral tests believed to be sensitive to cocaine action. Acute administration of dimethocaine (10–40 mg/kg, IP) significantly increased locomotor activity and time spent on the drug-paired side and reduced the relative number of entries and time spent on the open arms of the plus-maze in mice. Procaine (20–50 mg/kg, IP) failed to affect these responses. These data demonstrate the locomotor stimulant, reinforcing and anxiogenic actions of dimethocaine similar to those reported for cocaine in animals. In addition, these findings support a role for dopaminergic activity, rather than local anesthetic action, in the behavioral effects caused by dimethocaine.

Non-RCT

Animal Study

Study Snapshot

Dimethocaine exhibits locomotor stimulant, reinforcing, and anxiogenic effects in mice, similar to cocaine, with dopaminergic activity playing a role in these behavioral effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects

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References

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The syntheses, characterization and in vitro metabolism of nitracaine, methoxypiperamide and mephtetramine.

Nitracaine, methoxypiperamide, and mephtetramine were synthesized and analyzed using our SAM protocol, highlighting the ability of academic research labs to quickly respond to emerging new psychoactive substances.