Comparative biological activities of the four synthetic (5,6)-dihete isomers.

doi:10.1016/0090-6980(89)90046-4

Paper

DOI: 10.1016/0090-6980(89)90046-4

Comparative biological activities of the four synthetic (5,6)-dihete isomers.

Published Dec 1, 1989 · A. Muller, E. Rechencq, C. Kugel

Prostaglandins

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Abstract

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In Vitro Study

Study Snapshot

The synthetic (5,6)-dihete isomer (5S,6R) shows LTD4 receptor recognition and contraction of the ileum in vitro, suggesting potential LTD4-like activity when produced in large concentrations.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1073/PNAS.86.9.3438

Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: evidence for competition at a common receptor.

Lipoxin A4 competes with leukotriene D4 for binding to rat glomerular mesangial cells, preventing LTD4-induced inositol trisphosphate generation and preventing LTD4-induced reductions in glomerular filtration rate in vivo.

1989·157citations·K. Badr et al.·Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

DOI:

Comparative activity of leukotriene D4, 5,6-dihydroxy-eicosatetraenoic acid and lipoxin A on guinea pig lung parenchyma and ileum smooth muscle.

Leukotriene D4 is more potent than 5,6-DiHETE and lipoxin A in inducing contractile responses in guinea pig lung parenchyma and ileum smooth muscle, suggesting less specific lung LTD4 receptors than ileum LTD4 receptors.

1988·7citations·J. Cristol et al.·Research communications in chemical pathology and pharmacology

Research communications in chemical pathology and pharmacology

DOI: 10.1016/0005-2760(88)90233-0

Enzymatic formation of 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid: kinetics of the reaction and stereochemistry of the product.

The enzyme mouse liver cytosolic epoxide hydrolase catalyzes the enzymatic conversion of leukotriene A4 into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid, with the product having the stereochemistry established as (5S

1988·17citations·J. Haeggström et al.·Biochimica et biophysica acta

Biochimica et biophysica acta

DOI:

The 6R-oxygenase activity of arachidonate 5-lipoxygenase purified from porcine leukocytes.

The purified 5-lipoxygenase from porcine leukocytes exhibits 6R-oxygenase activity with (5S)-hydroxy and (5S)-hydroperoxy acids as substrates, suggesting it is an integral part of the enzyme's function.

1988·27citations·N. Ueda et al.·The Journal of biological chemistry

The Journal of biological chemistry

DOI: 10.1016/s0022-3565(25)39311-0

Inhibition of 3H-leukotriene D4 binding to guinea pig lung receptors by the novel leukotriene antagonist ICI 198,615.

ICI 198,615 is a novel, highly potent, and selective antagonist of leukotriene D4 receptors, with potential applications in treating inflammatory diseases.

1987·22citations·D. Aharony et al.·The Journal of pharmacology and experimental therapeutics

The Journal of pharmacology and experimental therapeutics

Citations

DOI: 10.3389/fimmu.2021.691216

Subgingival Microbiome and Specialized Pro-Resolving Lipid Mediator Pathway Profiles Are Correlated in Periodontal Inflammation

Periodontal inflammation is linked to distinct profiles of lipid mediators, receptor genes, and subgingival microbiome, suggesting lipid mediators influence microbial composition in periodontitis.

2021·19citations·Chun-Teh Lee et al.·Frontiers in Immunology

Frontiers in Immunology

DOI: 10.1155/2017/9632018

Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs

NSAID use may promote inflammation and cancer, and future agents may help optimize treatment by reducing inflammation and cancer risks.

2017·3citations·A. Kyriakopoulos et al.·International Journal of Inflammation

International Journal of Inflammation

DOI: 10.1021/acs.biochem.5b01339

Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential.

Human epithelial 15-lipoxygenase-2 (h15-LOX-2) exhibits strict regiospecificity, limiting its role in transcellular synthesis of lipoxins.

2016·20citations·A. Green et al.·Biochemistry

Biochemistry

DOI: 10.1016/0014-5793(92)80593-6

Conversion of 5,6‐dihydroxyeicosatetraenoic acids A novel pathway for lipoxin formation by human platelets

Lipoxygenation at C-15 of 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acids may be a novel pathway for platelet-dependent lipoxin formation.

1992·18citations·S. Tornhamre et al.·FEBS Letters

FEBS Letters

DOI: 10.1002/jlb.49.3.283

6‐Trans‐Leukotriene B4 Is a Neutrophil Chemotaxin in the Guinea Pig Dermis

6trans-leukotriene B4 is a more potent neutrophil chemoattractant than 12(R)-hydroxyeicosatetraenoic acid in the guinea pig dermis, but less potent than leukotriene B4.

1991·4citations·D. Fretland et al.·Journal of Leukocyte Biology

Journal of Leukocyte Biology