D. Azarifar, H. Ghasemnejad-Bosra
Apr 1, 2006
Citations
0
Influential Citations
25
Citations
Journal
Synthesis
Abstract
1,3-Dibromo-5,5-dimethylhydantoin (DBH) has been found to efficiently catalyze the one-pot conversion of various N-arylglycines through N-nitrosation and cyclization to sydnones in combination with NaNO 2 and Ac 2 O in high yields (80-94%) under mild and neutral conditions. Also, it was shown that DBH can conveniently promote the bromination of these sydnones to their 4-bromo substituted congeners in excellent yields in DMF at room temperature.