The toxic and anti-feedant activity of 2H-pyridazin-3-one-substituted 1,3,4-oxadiazoles against the armyworm Pseudaletia separata (Walker) and other insects and mites.

doi:10.1002/PS.704

Paper

The toxic and anti-feedant activity of 2H-pyridazin-3-one-substituted 1,3,4-oxadiazoles against the armyworm Pseudaletia separata (Walker) and other insects and mites.

Published Aug 1, 2003 · Qingchun Huang, X. Qian, G. Song

Pest management science

Q1 SJR score

30

Citations

2

Influential Citations

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Abstract

The toxicities and anti-feedant activities of thirteen asymmetrical 1,3,4-oxadiazoles containing a 2H-pyridazin-3-one group were investigated. The compounds were shown to possess considerable activity in retarding the development of larvae of a number of Lepidoptera, but they were all inactive against Homoptera, Diptera and Acarina. The compounds had powerful anti-feedant activity comparable with that of azadirachtin. The toxic symptoms of the poisoned larvae indicated that the compounds were novel insect growth regulators with a mode of action that might be similar to the chitin-synthesis inhibition of oxadiazole compounds and/or the juvenile hormone effect of pyridazinone compounds.

In Vitro Study

Study Snapshot

2H-pyridazin-3-one-substituted 1,3,4-oxadiazoles effectively retard larval development of Lepidoptera, with comparable anti-feedant activity to azadirachtin, but inactive against Homoptera, Diptera, and Acarin

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The toxic and anti-feedant activity of 2H-pyridazin-3-one-substituted 1,3,4-oxadiazoles against the armyworm Pseudaletia separata (Walker) and other insects and mites.

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References

Citations

Design, synthesis and biological evaluation of novel 3-phenylpropanamide derivatives with acyl hydrazone units

Novel 3-phenylpropanamide derivatives with acyl hydrazone units show excellent antibacterial activity against Xanthomonas oryzae, Ralstonia solanacearum, and phytopathogenic fungi, offering potential as antibacterial reagents in the future.

Insecticidal activity of some synthesized 1,3,4-oxadiazole derivatives grafted on chitosan and polymethylmethacrylate against the cotton leafworm Spodoptera littoralis.

Compounds 2a, 2b, 6a, and 6d show promising insecticidal activity against cotton leafworm Spodoptera littoralis larvae, with the least cytotoxicity to humans.

Design, synthesis, and bioactivities of novel pyridazinone derivatives containing 2‐phenylthiazole or oxazole skeletons

Novel pyridazinone derivatives show potent insecticidal and fungicidal activities against various pests, with compound 12b showing particularly remarkable activity against Aphis fabae.

Cytotoxic selectivity and apoptosis induction of piericidin A contributes potentially to its insecticidal effect against Mythimna separata (Lepidoptera: Noctuidae) larvae.

Piericidin A shows considerable insecticidal activity against Mythimna separata larvae, with its cytotoxic selectivity and apoptosis induction potentially contributing to its insecticidal effect against insect pests.

Diverse Biologically Active Pyridazine Analogs: A Scaffold for the Highly Functionalized Heterocyclic Compounds

Pyridazines and phthalazines show diverse biological properties, including antifeeedant, insecticidal, herbicidal, molluscicidal, plant growth regulator, and cardiovascular disease treatment, making them attractive synthetic compounds for designing and developing novel drugs.

Cytotoxicity evaluation and apoptosis-inducing effects of furanone analogues in insect cell line SL2

Compound 14 shows potential as a new potent insecticide with less toxicity than human cells, inducing apoptosis through a caspase-dependent mitochondrial pathway.

The competence of hemocyte immunity in the armyworm Mythimna separata larvae to sublethal hexaflumuron exposure.

Sublethal hexaflumuron exposure reduces Mythimna separata larval survival by depressing the competence of hemocyte-mediated immune responses.