Biological Activity of a 4-Hydroxy-Furanyl-Benzamide Derivative on Heart Failure

doi:10.1055/a-1855-1412

Paper

Biological Activity of a 4-Hydroxy-Furanyl-Benzamide Derivative on Heart Failure

Published Apr 19, 2022 · Figueroa‐Valverde Lauro, Rosas-Nexticapa Marcela, López-Ramos Maria

Drug Research

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Abstract

Abstract Background There are studies that suggest that some benzamide derivatives may exert effects on heart failure; however, their molecular mechanism is not very clear. Objective The aim of this research was to evaluate the biological activity of a 4-hydroxy-furanyl-benzamide derivative against heart failure translated as area infarct. Methods Biological activity produced by 4-hydroxy-furanyl-benzamide derivative against heart failure was determinate using an ischemia-reperfusion injury model. In addition, the effects exerted by the 4-hydroxy-furanyl-benzamide derivative on left ventricular pressure (LVP) was evaluated in the absence or presence of some drugs such as yohimbine, butaxamine, methoctramine and L-NAME using a model of rat heart isolated. Results The results showed that 4-hydroxy-furanyl-benzamide derivative decrease both infarct area and LVP. However, the effect produced by 4-hydroxy-furanyl-benzamide derivative on LVP was inhibited in the presence of both methoctramine and L-NAME. Conclusions All these data suggest that biological activity produced by 4-hydroxy-furanyl-benzamide derivative on left ventricular pressure is through of both M 2 -muscarinic receptor and nitric oxide synthase enzyme activation. It is important to mention that this phenomenon results as a decrease of both infarct area and heart failure.

Non-RCT

Animal Study

Study Snapshot

4-hydroxy-furanyl-benzamide derivative decreases infarct area and left ventricular pressure, potentially through M2 -muscarinic receptor and nitric oxide synthase enzyme activation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Biological Activity of a 4-Hydroxy-Furanyl-Benzamide Derivative on Heart Failure

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Citations